Regulation of masculinization: Androgen signalling for external genitalia development

Shoko Matsushita, Kentaro Suzuki, Aki Murashima, Daiki Kajioka, Alvin Resultay Acebedo, Shinichi Miyagawa, Ryuma Haraguchi, Yukiko Ogino, Gen Yamada

研究成果: ジャーナルへの寄稿評論記事

6 引用 (Scopus)

抄録

The biology of masculinization is fundamentally important for understanding the embryonic developmental processes that are involved in the development of the male reproductive tract, external genitalia, and also the tumorigenesis of prostate cancer. The molecular mechanisms of masculinization are of interest to many researchers and clinicians involved in varied fields, including molecular developmental biology, cancer research, endocrinology, and urology. Androgen signalling is mediated by the nuclear androgen receptor, which has fundamental roles in masculinization during development. Various modes of androgen signalling, including 5α-dihydrotestosterone-induced regulation of mesenchymal cell proliferation, have been observed in masculinization. Such regulation is essential for regulating urogenital tissue development, including external genitalia development. Androgen-induced genes, such as MAFB, which belongs to the activator protein 1 (AP-1) superfamily of genes, have essential roles in male urethral formation, and disruption of its signalling can interfere with urethral formation, which often results in hypospadias. Another AP-1 superfamily gene, ATF3, could be responsible for some instances of hypospadias in humans. These androgen-dependent signals and downstream events are crucial for not only developmental processes but also processes of diseases such as hypospadias and prostate cancer.

元の言語英語
ページ(範囲)358-368
ページ数11
ジャーナルNature Reviews Urology
15
発行部数6
DOI
出版物ステータス出版済み - 6 1 2018

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Genitalia
Hypospadias
Androgens
Transcription Factor AP-1
Prostatic Neoplasms
Developmental Biology
Dihydrotestosterone
Endocrinology
Essential Genes
Androgen Receptors
Urology
Cytoplasmic and Nuclear Receptors
Genes
Molecular Biology
Carcinogenesis
Research Personnel
Cell Proliferation
Research
Neoplasms

All Science Journal Classification (ASJC) codes

  • Urology

これを引用

Matsushita, S., Suzuki, K., Murashima, A., Kajioka, D., Acebedo, A. R., Miyagawa, S., ... Yamada, G. (2018). Regulation of masculinization: Androgen signalling for external genitalia development. Nature Reviews Urology, 15(6), 358-368. https://doi.org/10.1038/s41585-018-0008-y

Regulation of masculinization : Androgen signalling for external genitalia development. / Matsushita, Shoko; Suzuki, Kentaro; Murashima, Aki; Kajioka, Daiki; Acebedo, Alvin Resultay; Miyagawa, Shinichi; Haraguchi, Ryuma; Ogino, Yukiko; Yamada, Gen.

:: Nature Reviews Urology, 巻 15, 番号 6, 01.06.2018, p. 358-368.

研究成果: ジャーナルへの寄稿評論記事

Matsushita, S, Suzuki, K, Murashima, A, Kajioka, D, Acebedo, AR, Miyagawa, S, Haraguchi, R, Ogino, Y & Yamada, G 2018, 'Regulation of masculinization: Androgen signalling for external genitalia development', Nature Reviews Urology, 巻. 15, 番号 6, pp. 358-368. https://doi.org/10.1038/s41585-018-0008-y
Matsushita S, Suzuki K, Murashima A, Kajioka D, Acebedo AR, Miyagawa S その他. Regulation of masculinization: Androgen signalling for external genitalia development. Nature Reviews Urology. 2018 6 1;15(6):358-368. https://doi.org/10.1038/s41585-018-0008-y
Matsushita, Shoko ; Suzuki, Kentaro ; Murashima, Aki ; Kajioka, Daiki ; Acebedo, Alvin Resultay ; Miyagawa, Shinichi ; Haraguchi, Ryuma ; Ogino, Yukiko ; Yamada, Gen. / Regulation of masculinization : Androgen signalling for external genitalia development. :: Nature Reviews Urology. 2018 ; 巻 15, 番号 6. pp. 358-368.
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