Regulation of metabolic pathways in steroidogenic cells by Ad4BP/SF-1

研究成果: Chapter in Book/Report/Conference proceedingChapter

抄録

Ad4BP/SF-1 (NR5A1), a member of the nuclear receptor superfamily, is known to play crucial roles in the regulation of steroidogenesis in the gonads and adrenal cortex, and many studies have demonstrated that all steroidogenic genes are direct targets of Ad4BP/SF-1. In addition, in vivo KO studies demonstrated that no steroidogenic organs formed in gene-disrupted mice, strongly suggesting that Ad4BP/SF-1 is essential for the development of the gonads and adrenal gland. However, it remains unclear how Ad4BP/SF-1 regulates the development of the steroidogenic organs and which additional non-steroidogenic genes are targeted. We surveyed the target genes of Ad4BP/SF-1 in steroidogenic cells by mRNA deep sequencing and ChIP-sequence analyses using an Ad4BP/SF-1 antibody. Nearly all genes in energy-producing glycolytic pathways were found to be regulated by Ad4BP/SF-1. We also showed that the key genes implicated in NADPH production are the direct targets. Since sufficient supplies of ATP and NADPH are necessary for cellular survival and production of steroids, Ad4BP/SF-1 possibly orchestrates tissue-specific steroidogenic pathway and these housekeeping metabolic pathways.

本文言語英語
ホスト出版物のタイトルCell Biology of the Ovary
ホスト出版物のサブタイトルStem Cells, Development, Cancer, and Clinical Aspects
出版社Springer Singapore
ページ35-43
ページ数9
ISBN(電子版)9789811079412
ISBN(印刷版)9789811079405
DOI
出版ステータス出版済み - 6 12 2018

All Science Journal Classification (ASJC) codes

  • 医学(全般)
  • 健康専門職(全般)

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