Regulation of novel superoxide-producing NAD(P)H oxidases

Ryu Takeya, Hideki Sumimoto

研究成果: Contribution to journalReview article査読

63 被引用数 (Scopus)

抄録

Deliberate production of reactive oxygen species (ROS) are catalyzed by enzymes that belong to the NAD(P)H oxidase (Nox) family. The human genome contains seven members of the Nox family: the superoxide-producing enzymes Nox1 through Nox5 and the dual oxidases Duox1 and Duox2 that release hydrogen peroxide but not superoxide. Among them, the classical member gp91 phox/Nox2 functions as the phagocyte NADPH oxidase, playing a crucial role in host defense. Although Nox2, heterodimerized with its membrane-spanning partner p22phox, is inactive in resting cells, during phagocytosis it forms an active complex with soluble regulatory proteins such as the organizer p47phox, the activator p67phox, and the small GTPase Rac. Here the authors describe how the novel superoxide-producing Nox oxidases (Nox1, 3, 4, and 5) with different functions are regulated by p22 phox, the Nox organizers, the Nox activators, and Rac, and how their expression is controlled at the transcriptional level.

本文言語英語
ページ(範囲)1523-1532
ページ数10
ジャーナルAntioxidants and Redox Signaling
8
9-10
DOI
出版ステータス出版済み - 9 1 2006

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Physiology
  • Molecular Biology
  • Clinical Biochemistry
  • Cell Biology

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