TY - JOUR
T1 - Regulation of novel superoxide-producing NAD(P)H oxidases
AU - Takeya, Ryu
AU - Sumimoto, Hideki
PY - 2006/9/1
Y1 - 2006/9/1
N2 - Deliberate production of reactive oxygen species (ROS) are catalyzed by enzymes that belong to the NAD(P)H oxidase (Nox) family. The human genome contains seven members of the Nox family: the superoxide-producing enzymes Nox1 through Nox5 and the dual oxidases Duox1 and Duox2 that release hydrogen peroxide but not superoxide. Among them, the classical member gp91 phox/Nox2 functions as the phagocyte NADPH oxidase, playing a crucial role in host defense. Although Nox2, heterodimerized with its membrane-spanning partner p22phox, is inactive in resting cells, during phagocytosis it forms an active complex with soluble regulatory proteins such as the organizer p47phox, the activator p67phox, and the small GTPase Rac. Here the authors describe how the novel superoxide-producing Nox oxidases (Nox1, 3, 4, and 5) with different functions are regulated by p22 phox, the Nox organizers, the Nox activators, and Rac, and how their expression is controlled at the transcriptional level.
AB - Deliberate production of reactive oxygen species (ROS) are catalyzed by enzymes that belong to the NAD(P)H oxidase (Nox) family. The human genome contains seven members of the Nox family: the superoxide-producing enzymes Nox1 through Nox5 and the dual oxidases Duox1 and Duox2 that release hydrogen peroxide but not superoxide. Among them, the classical member gp91 phox/Nox2 functions as the phagocyte NADPH oxidase, playing a crucial role in host defense. Although Nox2, heterodimerized with its membrane-spanning partner p22phox, is inactive in resting cells, during phagocytosis it forms an active complex with soluble regulatory proteins such as the organizer p47phox, the activator p67phox, and the small GTPase Rac. Here the authors describe how the novel superoxide-producing Nox oxidases (Nox1, 3, 4, and 5) with different functions are regulated by p22 phox, the Nox organizers, the Nox activators, and Rac, and how their expression is controlled at the transcriptional level.
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U2 - 10.1089/ars.2006.8.1523
DO - 10.1089/ars.2006.8.1523
M3 - Review article
C2 - 16987008
AN - SCOPUS:33750897683
VL - 8
SP - 1523
EP - 1532
JO - Antioxidants and Redox Signaling
JF - Antioxidants and Redox Signaling
SN - 1523-0864
IS - 9-10
ER -