Regulation of primordial follicle formation, dormancy, and activation in mice

研究成果: Contribution to journalArticle査読

2 被引用数 (Scopus)

抄録

In female reproduction, the oocyte number is limited after birth. To achieve a continuous ovulatory cycle, oocytes are stored in primordial follicles. Therefore, the regulation of primordial follicle dormancy and activation is important for reproductive sustainability, and its collapse leads to premature ovarian insufficiency. In this review, we summarize primordial follicle development and the molecular mechanisms underlying primordial follicle maintenance and activation in mice. We also overview the mechanisms discovered through in vitro culture of functional oocytes, including the establishment of primordial follicle induction by environmental factors, which revealed the importance of hypoxia and compression by the extra cellular matrix (ECM) for primordial follicle maintenance in vivo.

本文言語英語
ページ(範囲)189-195
ページ数7
ジャーナルThe Journal of reproduction and development
67
3
DOI
出版ステータス出版済み - 6 21 2021
外部発表はい

All Science Journal Classification (ASJC) codes

  • 動物科学および動物学

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