Regulation of the cell cycle by SCF-type ubiquitin ligases

Keiichi Nakayama, Keiko Nakayama

研究成果: ジャーナルへの寄稿評論記事

256 引用 (Scopus)

抄録

Regulation of the cell cycle is dependent on protein degradation by the ubiquitin-proteasome system. Two major ubiquitin ligases, the anaphase-promoting complex or cyclosome (APC/C) and SCF complex, are responsible for the periodic proteolysis of many regulators of the cell cycle. The receptor component of the SCF complex is one of many F-box proteins, three of which - Skp2, Fbw7, and β-TrCP - are well characterized and implicated in cell cycle regulation. We have generated mice deficient in Skp2, Fbw7, or β-TrCP1 and have identified the roles of these proteins in both cell cycle regulation and mouse development. Clinical evidence also suggests that dysregulation of these F-box proteins contributes to human cancers.

元の言語英語
ページ(範囲)323-333
ページ数11
ジャーナルSeminars in Cell and Developmental Biology
16
発行部数3
DOI
出版物ステータス出版済み - 1 1 2005

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SKP Cullin F-Box Protein Ligases
Cell Cycle
F-Box Proteins
Ubiquitin
Proteolysis
Anaphase-Promoting Complex-Cyclosome
Proto-Oncogene Proteins c-kit
Proteasome Endopeptidase Complex
Ligases
Neoplasms
Proteins

All Science Journal Classification (ASJC) codes

  • Developmental Biology
  • Cell Biology

これを引用

Regulation of the cell cycle by SCF-type ubiquitin ligases. / Nakayama, Keiichi; Nakayama, Keiko.

:: Seminars in Cell and Developmental Biology, 巻 16, 番号 3, 01.01.2005, p. 323-333.

研究成果: ジャーナルへの寄稿評論記事

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