TY - JOUR
T1 - Regulation of the replication cycle
T2 - Conserved and diverse regulatory systems for DnaA and oriC
AU - Katayama, Tsutomu
AU - Ozaki, Shogo
AU - Keyamura, Kenji
AU - Fujimitsu, Kazuyuki
N1 - Funding Information:
We apologize to all researchers in this field whose work could not be cited because of space limitations. Our study is supported mainly by the Grant-in-Aid for Scientific Research from the Ministry of Education, Culture, Sports, Science and Technology of Japan.
PY - 2010/3
Y1 - 2010/3
N2 - Chromosomal replication must be limited to once and only once per cell cycle. This is accomplished by multiple regulatory pathways that govern initiator proteins and replication origins. A principal feature of DNA replication is the coupling of the replication reaction to negative-feedback regulation. Some of the factors that are important in this process have been discovered, including the clamp (DNA polymerase III subunit-Β (DnaN)), the datA locus, SeqA, DnaA homologue protein (Hda) and YabA, as well as factors that are involved at other stages of the regulatory mechanism, such as DnaA initiator-associating protein (DiaA), the DnaA-reactivating sequence (DARS) loci and Soj. Here, we describe the regulation of DnaA, one of the central proteins involved in bacterial DNA replication, by these factors in Escherichia coli, Bacillus subtilis and Caulobacter crescentus.
AB - Chromosomal replication must be limited to once and only once per cell cycle. This is accomplished by multiple regulatory pathways that govern initiator proteins and replication origins. A principal feature of DNA replication is the coupling of the replication reaction to negative-feedback regulation. Some of the factors that are important in this process have been discovered, including the clamp (DNA polymerase III subunit-Β (DnaN)), the datA locus, SeqA, DnaA homologue protein (Hda) and YabA, as well as factors that are involved at other stages of the regulatory mechanism, such as DnaA initiator-associating protein (DiaA), the DnaA-reactivating sequence (DARS) loci and Soj. Here, we describe the regulation of DnaA, one of the central proteins involved in bacterial DNA replication, by these factors in Escherichia coli, Bacillus subtilis and Caulobacter crescentus.
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U2 - 10.1038/nrmicro2314
DO - 10.1038/nrmicro2314
M3 - Review article
C2 - 20157337
AN - SCOPUS:76949086750
VL - 8
SP - 163
EP - 170
JO - Nature Reviews Microbiology
JF - Nature Reviews Microbiology
SN - 1740-1526
IS - 3
ER -
