Regulation of Vav localization in membrane rafts by adaptor molecules Grb2 and BLNK

Sachiko Johmura, Masatsugu Oh-hora, Kazunori Inabe, Yumiko Nishikawa, Katsuhiko Hayashi, Elena Vigorito, Daisuke Kitamura, Martin Turner, Koh Shingu, Masaki Hikida, Tomohiro Kurosaki

研究成果: Contribution to journalArticle査読

55 被引用数 (Scopus)

抄録

Despite the importance of the Vav family proteins for B cell receptor (BCR) signaling, their activation mechanisms remain poorly understood. We demonstrate here that adaptor molecules Grb2 and BLNK, in addition to Vav, are required for efficient Rac1 activation in response to BCR stimulation. Loss of either Grb2 or BLNK results in decreased translocation of Vav3 to membrane rafts. By expression of Vav3 as a raft-targeted construct, the defective Rac1 activation in Grb2- or BLNK-deficient B cells is restored. Hence, our findings suggest that Grb2 and BLNK cooperate to localize Vav into membrane rafts, thereby contributing to optimal activation of Vav in B cells.

本文言語英語
ページ(範囲)777-787
ページ数11
ジャーナルImmunity
18
6
DOI
出版ステータス出版済み - 6 1 2003
外部発表はい

All Science Journal Classification (ASJC) codes

  • 免疫アレルギー学
  • 免疫学
  • 感染症

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