Regulatory effects of purine and pyrimidine nucleoside 5'-di(Tri)- phosphate-3'-diphosphates on eucaryote protein synthesis

Jun Ichiro Mukai, Masato Furuichi, Sawao Murao, Toyokazu Nishino

研究成果: Contribution to journalArticle査読

9 被引用数 (Scopus)

抄録

Adenosine-, guanosine-, cytidine- and uridine-5'-di(tri)-phosphate-3'-diphosphates were enzymatically prepared by the use of Streptomyces adephospholyticus ATP nucleotide pyrophospho- kinase (E.C. 2.7.6.4). Their regulatory effects were then investigated on translation of rat liver, rabbit globin and silkworm pupae chorion mRNAs by the wheat germ lysate system in vitro. They were found to exert base-specific and mRNA species-specific stimulatory or inhibitory effects, respectively. In particular, cytidine 5'-diphosphate-3'-diphosphate stimulated chorion mRNA translation 3-fold. The significance and limitations of the findings were discussed in relation to natural occurrence and possible regulatory functions of the nucleotides in eucaryotes.

本文言語英語
ページ(範囲)1775-1781
ページ数7
ジャーナルAgricultural and Biological Chemistry
45
8
DOI
出版ステータス出版済み - 8 1981

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

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