Regulatory T cells

Hideya Onishi, Takashi Morisaki, Mitsuo Katano

研究成果: 書籍/レポート タイプへの寄稿

抄録

Regulatory T cells (Tregs) are CD4+ T cells that inhibit autoreactive effector T cells to suppress antitumor immunity. Many anticancer therapeutics have limited efficacy, and it is thought that Tregs may, in part, be one of the reasons. From this viewpoint, Tregs may be a therapeutic target for cancer immunotherapy. Tregs also play a pivotal role in the induction of self-tolerance, and their dysfunction may lead to autoimmune disease. Promising results have recently been reported on the molecular targeting of drugs to Tregs. In the near future, the regulation of Tregs may be a central point for cancer immunotherapy. In this chapter, we focus on the immune-suppressing mechanism of Tregs and the development of strategies to modulate Tregs.

本文言語英語
ホスト出版物のタイトルImmunotherapy of Cancer
ホスト出版物のサブタイトルAn Innovative Treatment Comes of Age
出版社Springer Japan
ページ309-322
ページ数14
ISBN(電子版)9784431550310
ISBN(印刷版)9784431550303
DOI
出版ステータス出版済み - 2月 22 2016

!!!All Science Journal Classification (ASJC) codes

  • 医学(全般)

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