Relapse patterns and predictors of IgG4-related diseases involved with autoimmune pancreatitis: A single-center retrospective study of 115 patients

Masami Miki, Nao Fujimori, takamasa ono, Ken Kawabe, Akihisa Ohno, Kazuhide Matsumoto, Katsuhito Teramatsu, Yuichi Tachibana, Yoshihiro Ogawa

研究成果: ジャーナルへの寄稿記事

抄録

Objective: Autoimmune pancreatitis is an autoimmune disorder accompanied by clinicopathological manifestations that have been established as immunoglobulin (IgG)4-related diseases (IgG4-RD). Other IgG4-RD are often involved with autoimmune pancreatitis. They sometimes relapse despite a favorable response to steroid therapy. This study aimed to clarify the patterns and risk factors for extrapancreatic relapse. Methods: We reviewed the data of 115 patients diagnosed with definite autoimmune pancreatitis type 1 and followed up for > 1 year. We analyzed two items: the timing and pattern of extrapancreatic relapse, and risk factors for relapse with three common manifestations: IgG4-related sclerosing cholangitis (SC), IgG4-related dacryoadenitis and sialadenitis (DS), and IgG4-related retroperitoneal fibrosis (RF). Results: Remission was achieved in all patients, except one. The extrapancreatic relapse rates were 11.0%, 19.7%, and 40% within 3, 5, and 10 years, respectively. Of 26 patients with extrapancreatic relapse, nine (34.6%) relapsed with a new IgG4-RD. Based on multivariate analysis, the interval between symptom onset and steroid initiation, and the presence of RF at onset were significant risk factors for relapse with SC and RF, respectively. Conclusions: Our results indicate that they may be various extrapancreatic relapse patterns especially in autoimmune pancreatitis with other organ involvement. Patients with a delayed initiation of steroids or RF at onset should be carefully followed up as high-risk groups for SC and RF relapse.

元の言語英語
ページ(範囲)152-158
ページ数7
ジャーナルJournal of Digestive Diseases
20
発行部数3
DOI
出版物ステータス出版済み - 3 1 2019

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Pancreatitis
Retrospective Studies
Immunoglobulin G
Retroperitoneal Fibrosis
Recurrence
Sclerosing Cholangitis
Steroids
Dacryocystitis
Sialadenitis
Immunoglobulins
Multivariate Analysis

All Science Journal Classification (ASJC) codes

  • Gastroenterology

これを引用

Relapse patterns and predictors of IgG4-related diseases involved with autoimmune pancreatitis : A single-center retrospective study of 115 patients. / Miki, Masami; Fujimori, Nao; ono, takamasa; Kawabe, Ken; Ohno, Akihisa; Matsumoto, Kazuhide; Teramatsu, Katsuhito; Tachibana, Yuichi; Ogawa, Yoshihiro.

:: Journal of Digestive Diseases, 巻 20, 番号 3, 01.03.2019, p. 152-158.

研究成果: ジャーナルへの寄稿記事

Miki, Masami ; Fujimori, Nao ; ono, takamasa ; Kawabe, Ken ; Ohno, Akihisa ; Matsumoto, Kazuhide ; Teramatsu, Katsuhito ; Tachibana, Yuichi ; Ogawa, Yoshihiro. / Relapse patterns and predictors of IgG4-related diseases involved with autoimmune pancreatitis : A single-center retrospective study of 115 patients. :: Journal of Digestive Diseases. 2019 ; 巻 20, 番号 3. pp. 152-158.
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abstract = "Objective: Autoimmune pancreatitis is an autoimmune disorder accompanied by clinicopathological manifestations that have been established as immunoglobulin (IgG)4-related diseases (IgG4-RD). Other IgG4-RD are often involved with autoimmune pancreatitis. They sometimes relapse despite a favorable response to steroid therapy. This study aimed to clarify the patterns and risk factors for extrapancreatic relapse. Methods: We reviewed the data of 115 patients diagnosed with definite autoimmune pancreatitis type 1 and followed up for > 1 year. We analyzed two items: the timing and pattern of extrapancreatic relapse, and risk factors for relapse with three common manifestations: IgG4-related sclerosing cholangitis (SC), IgG4-related dacryoadenitis and sialadenitis (DS), and IgG4-related retroperitoneal fibrosis (RF). Results: Remission was achieved in all patients, except one. The extrapancreatic relapse rates were 11.0{\%}, 19.7{\%}, and 40{\%} within 3, 5, and 10 years, respectively. Of 26 patients with extrapancreatic relapse, nine (34.6{\%}) relapsed with a new IgG4-RD. Based on multivariate analysis, the interval between symptom onset and steroid initiation, and the presence of RF at onset were significant risk factors for relapse with SC and RF, respectively. Conclusions: Our results indicate that they may be various extrapancreatic relapse patterns especially in autoimmune pancreatitis with other organ involvement. Patients with a delayed initiation of steroids or RF at onset should be carefully followed up as high-risk groups for SC and RF relapse.",
author = "Masami Miki and Nao Fujimori and takamasa ono and Ken Kawabe and Akihisa Ohno and Kazuhide Matsumoto and Katsuhito Teramatsu and Yuichi Tachibana and Yoshihiro Ogawa",
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T1 - Relapse patterns and predictors of IgG4-related diseases involved with autoimmune pancreatitis

T2 - A single-center retrospective study of 115 patients

AU - Miki, Masami

AU - Fujimori, Nao

AU - ono, takamasa

AU - Kawabe, Ken

AU - Ohno, Akihisa

AU - Matsumoto, Kazuhide

AU - Teramatsu, Katsuhito

AU - Tachibana, Yuichi

AU - Ogawa, Yoshihiro

PY - 2019/3/1

Y1 - 2019/3/1

N2 - Objective: Autoimmune pancreatitis is an autoimmune disorder accompanied by clinicopathological manifestations that have been established as immunoglobulin (IgG)4-related diseases (IgG4-RD). Other IgG4-RD are often involved with autoimmune pancreatitis. They sometimes relapse despite a favorable response to steroid therapy. This study aimed to clarify the patterns and risk factors for extrapancreatic relapse. Methods: We reviewed the data of 115 patients diagnosed with definite autoimmune pancreatitis type 1 and followed up for > 1 year. We analyzed two items: the timing and pattern of extrapancreatic relapse, and risk factors for relapse with three common manifestations: IgG4-related sclerosing cholangitis (SC), IgG4-related dacryoadenitis and sialadenitis (DS), and IgG4-related retroperitoneal fibrosis (RF). Results: Remission was achieved in all patients, except one. The extrapancreatic relapse rates were 11.0%, 19.7%, and 40% within 3, 5, and 10 years, respectively. Of 26 patients with extrapancreatic relapse, nine (34.6%) relapsed with a new IgG4-RD. Based on multivariate analysis, the interval between symptom onset and steroid initiation, and the presence of RF at onset were significant risk factors for relapse with SC and RF, respectively. Conclusions: Our results indicate that they may be various extrapancreatic relapse patterns especially in autoimmune pancreatitis with other organ involvement. Patients with a delayed initiation of steroids or RF at onset should be carefully followed up as high-risk groups for SC and RF relapse.

AB - Objective: Autoimmune pancreatitis is an autoimmune disorder accompanied by clinicopathological manifestations that have been established as immunoglobulin (IgG)4-related diseases (IgG4-RD). Other IgG4-RD are often involved with autoimmune pancreatitis. They sometimes relapse despite a favorable response to steroid therapy. This study aimed to clarify the patterns and risk factors for extrapancreatic relapse. Methods: We reviewed the data of 115 patients diagnosed with definite autoimmune pancreatitis type 1 and followed up for > 1 year. We analyzed two items: the timing and pattern of extrapancreatic relapse, and risk factors for relapse with three common manifestations: IgG4-related sclerosing cholangitis (SC), IgG4-related dacryoadenitis and sialadenitis (DS), and IgG4-related retroperitoneal fibrosis (RF). Results: Remission was achieved in all patients, except one. The extrapancreatic relapse rates were 11.0%, 19.7%, and 40% within 3, 5, and 10 years, respectively. Of 26 patients with extrapancreatic relapse, nine (34.6%) relapsed with a new IgG4-RD. Based on multivariate analysis, the interval between symptom onset and steroid initiation, and the presence of RF at onset were significant risk factors for relapse with SC and RF, respectively. Conclusions: Our results indicate that they may be various extrapancreatic relapse patterns especially in autoimmune pancreatitis with other organ involvement. Patients with a delayed initiation of steroids or RF at onset should be carefully followed up as high-risk groups for SC and RF relapse.

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