抄録
Solid-in-oil (S/O) nanodispersion systems represent a new technology that has been developed in the last decade. Nano-sized, solid-state, hydrophilic drug molecules can be dispersed in an oil vehicle by coating the drug with hydrophobic surfactants; these materials are designated here as S/O nanodispersions. Conventional S/O nanodispersion systems were devised to maintain hydrophilic enzymes in their active form in organic solvents. Because the coated molecules are stable in non-aqueous media, S/O nanodispersion systems can be successfully applied in oral and skin drug deliveries. It is known that the permeability of hydrophilic drugs through the skin decreases when the molecular weight of the drug exceeds 500 Da. In addition, hydrophobic molecules tend to permeate through the skin preferentially, compared with hydrophilic molecules, because the outermost layer of the skin is hydrophobic. In our experiments, the permeation of hydrophilic biomolecules such as peptides and proteins through the skin increased by 4-7 times when their molecules were coated with lipophilic surfactants and dispersed in an oil vehicle. Here, we introduce an efficient method for drug delivery through the skin, using the S/O nanodispersion technique.
| 元の言語 | 英語 |
|---|---|
| ホスト出版物のタイトル | Skin Permeation and Disposition of Therapeutic and Cosmeceutical Compounds |
| 出版者 | Springer Japan |
| ページ | 225-232 |
| ページ数 | 8 |
| ISBN（電子版） | 9784431565260 |
| ISBN（印刷物） | 9784431565246 |
| DOI | |
| 出版物ステータス | 出版済み - 11 28 2017 |
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All Science Journal Classification (ASJC) codes
- Medicine(all)
- Chemistry(all)
これを引用
Related topic : Solid-in-oil technique to increase skin permeation. / Kitaoka, Momoko; Goto, Masahiro.
Skin Permeation and Disposition of Therapeutic and Cosmeceutical Compounds. Springer Japan, 2017. p. 225-232.研究成果: 著書/レポートタイプへの貢献 › 章
}
TY - CHAP
T1 - Related topic
T2 - Solid-in-oil technique to increase skin permeation
AU - Kitaoka, Momoko
AU - Goto, Masahiro
PY - 2017/11/28
Y1 - 2017/11/28
N2 - Solid-in-oil (S/O) nanodispersion systems represent a new technology that has been developed in the last decade. Nano-sized, solid-state, hydrophilic drug molecules can be dispersed in an oil vehicle by coating the drug with hydrophobic surfactants; these materials are designated here as S/O nanodispersions. Conventional S/O nanodispersion systems were devised to maintain hydrophilic enzymes in their active form in organic solvents. Because the coated molecules are stable in non-aqueous media, S/O nanodispersion systems can be successfully applied in oral and skin drug deliveries. It is known that the permeability of hydrophilic drugs through the skin decreases when the molecular weight of the drug exceeds 500 Da. In addition, hydrophobic molecules tend to permeate through the skin preferentially, compared with hydrophilic molecules, because the outermost layer of the skin is hydrophobic. In our experiments, the permeation of hydrophilic biomolecules such as peptides and proteins through the skin increased by 4-7 times when their molecules were coated with lipophilic surfactants and dispersed in an oil vehicle. Here, we introduce an efficient method for drug delivery through the skin, using the S/O nanodispersion technique.
AB - Solid-in-oil (S/O) nanodispersion systems represent a new technology that has been developed in the last decade. Nano-sized, solid-state, hydrophilic drug molecules can be dispersed in an oil vehicle by coating the drug with hydrophobic surfactants; these materials are designated here as S/O nanodispersions. Conventional S/O nanodispersion systems were devised to maintain hydrophilic enzymes in their active form in organic solvents. Because the coated molecules are stable in non-aqueous media, S/O nanodispersion systems can be successfully applied in oral and skin drug deliveries. It is known that the permeability of hydrophilic drugs through the skin decreases when the molecular weight of the drug exceeds 500 Da. In addition, hydrophobic molecules tend to permeate through the skin preferentially, compared with hydrophilic molecules, because the outermost layer of the skin is hydrophobic. In our experiments, the permeation of hydrophilic biomolecules such as peptides and proteins through the skin increased by 4-7 times when their molecules were coated with lipophilic surfactants and dispersed in an oil vehicle. Here, we introduce an efficient method for drug delivery through the skin, using the S/O nanodispersion technique.
UR - http://www.scopus.com/inward/record.url?scp=85043671142&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85043671142&partnerID=8YFLogxK
U2 - 10.1007/978-4-431-56526-0_18
DO - 10.1007/978-4-431-56526-0_18
M3 - Chapter
AN - SCOPUS:85043671142
SN - 9784431565246
SP - 225
EP - 232
BT - Skin Permeation and Disposition of Therapeutic and Cosmeceutical Compounds
PB - Springer Japan
ER -