Relation of coffee consumption and serum liver enzymes in Japanese men and women with reference to effect modification of alcohol use and body mass index

Mizuko Ikeda, Takako Maki, Guang Yin, Hisaya Kawate, Masahiro Adachi, Keizo Ohnaka, Ryoichi Takayanagi, Suminori Kono

研究成果: ジャーナルへの寄稿記事

20 引用 (Scopus)

抄録

Objective. Previous studies have shown that coffee consumption is inversely related to serum levels of liver enzymes such as alanine aminotransferase (ALT), aspartate aminotransferase (AST), and gamma-glutamyl transferase (GGT), but few have addressed the relation in women and effect modifications of alcohol use and obesity. We examined the association of coffee and green tea consumption with serum activities of liver enzymes in free-living Japanese men and women, focusing on sex difference and effect modifications of alcohol and obesity. Material and methods. The data were derived from the baseline survey of the Kyushu University Fukuoka Cohort Study, and included 12,020 Japanese men and women aged 4976 years who were free of chronic liver diseases. Results. There was an inverse association between coffee consumption and elevated ALT in men, and the association between the two was weaker in women. In the analyses stratified by aminotransferases category, inverse associations of coffee consumption with serum activities of liver enzymes were observed in both men and women within the whole range and among those with aminotransferases within the reference range (ALT/AST ≤40 IU/L for men and ALT/AST ≤30 IU/L for women). Inverse associations of coffee with liver enzymes were more evident in those with high alcohol consumption and in those with low body mass index. Conclusions. Coffee drinking probably confers protection against alcohol-related increase in liver enzymes.

元の言語英語
ページ(範囲)171-179
ページ数9
ジャーナルScandinavian Journal of Clinical and Laboratory Investigation
70
発行部数3
DOI
出版物ステータス出版済み - 4 30 2010

Fingerprint

Coffee
Liver
Body Mass Index
Alcohols
Alanine Transaminase
Enzymes
Aspartate Aminotransferases
Serum
Transaminases
Obesity
Tea
Transferases
Sex Characteristics
Alcohol Drinking
Alanine
Drinking
Liver Diseases
Reference Values
Chronic Disease
Cohort Studies

All Science Journal Classification (ASJC) codes

  • Clinical Biochemistry

これを引用

Relation of coffee consumption and serum liver enzymes in Japanese men and women with reference to effect modification of alcohol use and body mass index. / Ikeda, Mizuko; Maki, Takako; Yin, Guang; Kawate, Hisaya; Adachi, Masahiro; Ohnaka, Keizo; Takayanagi, Ryoichi; Kono, Suminori.

:: Scandinavian Journal of Clinical and Laboratory Investigation, 巻 70, 番号 3, 30.04.2010, p. 171-179.

研究成果: ジャーナルへの寄稿記事

Ikeda, Mizuko ; Maki, Takako ; Yin, Guang ; Kawate, Hisaya ; Adachi, Masahiro ; Ohnaka, Keizo ; Takayanagi, Ryoichi ; Kono, Suminori. / Relation of coffee consumption and serum liver enzymes in Japanese men and women with reference to effect modification of alcohol use and body mass index. :: Scandinavian Journal of Clinical and Laboratory Investigation. 2010 ; 巻 70, 番号 3. pp. 171-179.
@article{996c0fe7dec946b58285aad536538179,
title = "Relation of coffee consumption and serum liver enzymes in Japanese men and women with reference to effect modification of alcohol use and body mass index",
abstract = "Objective. Previous studies have shown that coffee consumption is inversely related to serum levels of liver enzymes such as alanine aminotransferase (ALT), aspartate aminotransferase (AST), and gamma-glutamyl transferase (GGT), but few have addressed the relation in women and effect modifications of alcohol use and obesity. We examined the association of coffee and green tea consumption with serum activities of liver enzymes in free-living Japanese men and women, focusing on sex difference and effect modifications of alcohol and obesity. Material and methods. The data were derived from the baseline survey of the Kyushu University Fukuoka Cohort Study, and included 12,020 Japanese men and women aged 4976 years who were free of chronic liver diseases. Results. There was an inverse association between coffee consumption and elevated ALT in men, and the association between the two was weaker in women. In the analyses stratified by aminotransferases category, inverse associations of coffee consumption with serum activities of liver enzymes were observed in both men and women within the whole range and among those with aminotransferases within the reference range (ALT/AST ≤40 IU/L for men and ALT/AST ≤30 IU/L for women). Inverse associations of coffee with liver enzymes were more evident in those with high alcohol consumption and in those with low body mass index. Conclusions. Coffee drinking probably confers protection against alcohol-related increase in liver enzymes.",
author = "Mizuko Ikeda and Takako Maki and Guang Yin and Hisaya Kawate and Masahiro Adachi and Keizo Ohnaka and Ryoichi Takayanagi and Suminori Kono",
year = "2010",
month = "4",
day = "30",
doi = "10.3109/00365511003650165",
language = "English",
volume = "70",
pages = "171--179",
journal = "Scandinavian Journal of Clinical and Laboratory Investigation",
issn = "0036-5513",
publisher = "Informa Healthcare",
number = "3",

}

TY - JOUR

T1 - Relation of coffee consumption and serum liver enzymes in Japanese men and women with reference to effect modification of alcohol use and body mass index

AU - Ikeda, Mizuko

AU - Maki, Takako

AU - Yin, Guang

AU - Kawate, Hisaya

AU - Adachi, Masahiro

AU - Ohnaka, Keizo

AU - Takayanagi, Ryoichi

AU - Kono, Suminori

PY - 2010/4/30

Y1 - 2010/4/30

N2 - Objective. Previous studies have shown that coffee consumption is inversely related to serum levels of liver enzymes such as alanine aminotransferase (ALT), aspartate aminotransferase (AST), and gamma-glutamyl transferase (GGT), but few have addressed the relation in women and effect modifications of alcohol use and obesity. We examined the association of coffee and green tea consumption with serum activities of liver enzymes in free-living Japanese men and women, focusing on sex difference and effect modifications of alcohol and obesity. Material and methods. The data were derived from the baseline survey of the Kyushu University Fukuoka Cohort Study, and included 12,020 Japanese men and women aged 4976 years who were free of chronic liver diseases. Results. There was an inverse association between coffee consumption and elevated ALT in men, and the association between the two was weaker in women. In the analyses stratified by aminotransferases category, inverse associations of coffee consumption with serum activities of liver enzymes were observed in both men and women within the whole range and among those with aminotransferases within the reference range (ALT/AST ≤40 IU/L for men and ALT/AST ≤30 IU/L for women). Inverse associations of coffee with liver enzymes were more evident in those with high alcohol consumption and in those with low body mass index. Conclusions. Coffee drinking probably confers protection against alcohol-related increase in liver enzymes.

AB - Objective. Previous studies have shown that coffee consumption is inversely related to serum levels of liver enzymes such as alanine aminotransferase (ALT), aspartate aminotransferase (AST), and gamma-glutamyl transferase (GGT), but few have addressed the relation in women and effect modifications of alcohol use and obesity. We examined the association of coffee and green tea consumption with serum activities of liver enzymes in free-living Japanese men and women, focusing on sex difference and effect modifications of alcohol and obesity. Material and methods. The data were derived from the baseline survey of the Kyushu University Fukuoka Cohort Study, and included 12,020 Japanese men and women aged 4976 years who were free of chronic liver diseases. Results. There was an inverse association between coffee consumption and elevated ALT in men, and the association between the two was weaker in women. In the analyses stratified by aminotransferases category, inverse associations of coffee consumption with serum activities of liver enzymes were observed in both men and women within the whole range and among those with aminotransferases within the reference range (ALT/AST ≤40 IU/L for men and ALT/AST ≤30 IU/L for women). Inverse associations of coffee with liver enzymes were more evident in those with high alcohol consumption and in those with low body mass index. Conclusions. Coffee drinking probably confers protection against alcohol-related increase in liver enzymes.

UR - http://www.scopus.com/inward/record.url?scp=77951485927&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77951485927&partnerID=8YFLogxK

U2 - 10.3109/00365511003650165

DO - 10.3109/00365511003650165

M3 - Article

C2 - 20205615

AN - SCOPUS:77951485927

VL - 70

SP - 171

EP - 179

JO - Scandinavian Journal of Clinical and Laboratory Investigation

JF - Scandinavian Journal of Clinical and Laboratory Investigation

SN - 0036-5513

IS - 3

ER -