Relationship among tumor attenuation value of pre-contrast Computed Tomography (CT), washout rate and constituent cells in adrenal adenoma

Proposition of a new approach for diagnosing adrenal adenoma on Dynamic CT

Akihiro Nishie, Masaaki Sugimoto, Yoshiki Asayama, Kosei Ishigami, yasuhiro ushijima, Yukihisa Takayama, Daisuke Okamoto, nobuhiro fujita, Akira Yokomizo, Katsunori Tatsugami, Hiroshi Honda

研究成果: ジャーナルへの寄稿記事

1 引用 (Scopus)

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Aim: To elucidate the relationship among tumor attenuation of pre-contrast-enhanced (TApre) computed tomography (CT), washout rate and clear cell ratio (CCR) in adrenal adenoma (AA) and propose a new approach for diagnosing AA on dynamic CT. Materials and Methods: The training set consisted of 43 AAs and 15 non-AAs, while the validation set comprised 44 AAs and 11 non-AAs. Using the training set, the pairwise correlation between CCR, TApre and washout rate in AA was evaluated by linear regression analysis. A predictive formula for diagnosing AA was established by multiple logistic regression analysis using washout rate and TApre. Using the validation set, the diagnostic performance of this formula was investigated by comparing with the conventional diagnostic criteria: TApre ≤10 HU or washout rate ≥an optimal threshold calculated in the training set. Results: Washout rate increased as CCR decreased, and as TApre increased. The formula predicting the probability of AA was: P(AA)=1/{1+exp(-1.5257+0.4923× TApre-0.3264×washout rate)}. Diagnostic performance of this formula was sensitivity of 93.2% and accuracy of 89.1%, while for the conventional diagnostic criteria, sensitivity was 81.8-86.4% and accuracy 81.8-83.6%. Conclusion: The diagnostic potential of dynamic CT for diagnosing AA may be improved by changing the threshold of washout rate based on substituting TApre for CCR.

元の言語英語
ページ(範囲)4767-4773
ページ数7
ジャーナルAnticancer Research
38
発行部数8
DOI
出版物ステータス出版済み - 8 1 2018

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Adenoma
Tomography
Neoplasms
Regression Analysis
Linear Models
Logistic Models

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

これを引用

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title = "Relationship among tumor attenuation value of pre-contrast Computed Tomography (CT), washout rate and constituent cells in adrenal adenoma: Proposition of a new approach for diagnosing adrenal adenoma on Dynamic CT",
abstract = "Aim: To elucidate the relationship among tumor attenuation of pre-contrast-enhanced (TApre) computed tomography (CT), washout rate and clear cell ratio (CCR) in adrenal adenoma (AA) and propose a new approach for diagnosing AA on dynamic CT. Materials and Methods: The training set consisted of 43 AAs and 15 non-AAs, while the validation set comprised 44 AAs and 11 non-AAs. Using the training set, the pairwise correlation between CCR, TApre and washout rate in AA was evaluated by linear regression analysis. A predictive formula for diagnosing AA was established by multiple logistic regression analysis using washout rate and TApre. Using the validation set, the diagnostic performance of this formula was investigated by comparing with the conventional diagnostic criteria: TApre ≤10 HU or washout rate ≥an optimal threshold calculated in the training set. Results: Washout rate increased as CCR decreased, and as TApre increased. The formula predicting the probability of AA was: P(AA)=1/{1+exp(-1.5257+0.4923× TApre-0.3264×washout rate)}. Diagnostic performance of this formula was sensitivity of 93.2{\%} and accuracy of 89.1{\%}, while for the conventional diagnostic criteria, sensitivity was 81.8-86.4{\%} and accuracy 81.8-83.6{\%}. Conclusion: The diagnostic potential of dynamic CT for diagnosing AA may be improved by changing the threshold of washout rate based on substituting TApre for CCR.",
author = "Akihiro Nishie and Masaaki Sugimoto and Yoshiki Asayama and Kosei Ishigami and yasuhiro ushijima and Yukihisa Takayama and Daisuke Okamoto and nobuhiro fujita and Akira Yokomizo and Katsunori Tatsugami and Hiroshi Honda",
year = "2018",
month = "8",
day = "1",
doi = "10.21873/anticanres.12785",
language = "English",
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pages = "4767--4773",
journal = "Anticancer Research",
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TY - JOUR

T1 - Relationship among tumor attenuation value of pre-contrast Computed Tomography (CT), washout rate and constituent cells in adrenal adenoma

T2 - Proposition of a new approach for diagnosing adrenal adenoma on Dynamic CT

AU - Nishie, Akihiro

AU - Sugimoto, Masaaki

AU - Asayama, Yoshiki

AU - Ishigami, Kosei

AU - ushijima, yasuhiro

AU - Takayama, Yukihisa

AU - Okamoto, Daisuke

AU - fujita, nobuhiro

AU - Yokomizo, Akira

AU - Tatsugami, Katsunori

AU - Honda, Hiroshi

PY - 2018/8/1

Y1 - 2018/8/1

N2 - Aim: To elucidate the relationship among tumor attenuation of pre-contrast-enhanced (TApre) computed tomography (CT), washout rate and clear cell ratio (CCR) in adrenal adenoma (AA) and propose a new approach for diagnosing AA on dynamic CT. Materials and Methods: The training set consisted of 43 AAs and 15 non-AAs, while the validation set comprised 44 AAs and 11 non-AAs. Using the training set, the pairwise correlation between CCR, TApre and washout rate in AA was evaluated by linear regression analysis. A predictive formula for diagnosing AA was established by multiple logistic regression analysis using washout rate and TApre. Using the validation set, the diagnostic performance of this formula was investigated by comparing with the conventional diagnostic criteria: TApre ≤10 HU or washout rate ≥an optimal threshold calculated in the training set. Results: Washout rate increased as CCR decreased, and as TApre increased. The formula predicting the probability of AA was: P(AA)=1/{1+exp(-1.5257+0.4923× TApre-0.3264×washout rate)}. Diagnostic performance of this formula was sensitivity of 93.2% and accuracy of 89.1%, while for the conventional diagnostic criteria, sensitivity was 81.8-86.4% and accuracy 81.8-83.6%. Conclusion: The diagnostic potential of dynamic CT for diagnosing AA may be improved by changing the threshold of washout rate based on substituting TApre for CCR.

AB - Aim: To elucidate the relationship among tumor attenuation of pre-contrast-enhanced (TApre) computed tomography (CT), washout rate and clear cell ratio (CCR) in adrenal adenoma (AA) and propose a new approach for diagnosing AA on dynamic CT. Materials and Methods: The training set consisted of 43 AAs and 15 non-AAs, while the validation set comprised 44 AAs and 11 non-AAs. Using the training set, the pairwise correlation between CCR, TApre and washout rate in AA was evaluated by linear regression analysis. A predictive formula for diagnosing AA was established by multiple logistic regression analysis using washout rate and TApre. Using the validation set, the diagnostic performance of this formula was investigated by comparing with the conventional diagnostic criteria: TApre ≤10 HU or washout rate ≥an optimal threshold calculated in the training set. Results: Washout rate increased as CCR decreased, and as TApre increased. The formula predicting the probability of AA was: P(AA)=1/{1+exp(-1.5257+0.4923× TApre-0.3264×washout rate)}. Diagnostic performance of this formula was sensitivity of 93.2% and accuracy of 89.1%, while for the conventional diagnostic criteria, sensitivity was 81.8-86.4% and accuracy 81.8-83.6%. Conclusion: The diagnostic potential of dynamic CT for diagnosing AA may be improved by changing the threshold of washout rate based on substituting TApre for CCR.

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U2 - 10.21873/anticanres.12785

DO - 10.21873/anticanres.12785

M3 - Article

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SP - 4767

EP - 4773

JO - Anticancer Research

JF - Anticancer Research

SN - 0250-7005

IS - 8

ER -