TY - JOUR
T1 - Relationship between bone turnover markers and the heel stiffness index measured by quantitative ultrasound in middle-aged and elderly Japanese men
AU - Nishimura, Takayuki
AU - Arima, Kazuhiko
AU - Abe, Yasuyo
AU - Kanagae, Mitsuo
AU - Mizukami, Satoshi
AU - Okabe, Takuhiro
AU - Tomita, Yoshihito
AU - Goto, Hisashi
AU - Horiguchi, Itsuko
AU - Aoyagi, Kiyoshi
N1 - Funding Information:
Editor: Ziyuan Zhou. Funding: The study was supported in part by the Japan Society for the Promotion of Science. The authors have no conflicts of interest to disclose. aDepartment of Public Health, Nagasaki University Graduate School of Biomedical Sciences, Sakamoto, bDepartment of Rehabilitation, Nishi-Isahaya Hospital, Kaizumachi, cKen-Hoku Health Care Office, Tabiramachi, dCenter for Public Relations Strategy, Nagasaki University, Bunkyoumachi, Nagasaki, Japan. ∗Correspondence: Kazuhiko Arima, Department of Public Health, Nagasaki University Graduate School of Biomedical Sciences 1-12-4 Sakamoto, Nagasaki 852-8523, Japan (e-mail: kzarima-ngs@umin.ac.jp). Copyright © 2018 the Author(s). Published by Wolters Kluwer Health, Inc. This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Medicine (2018) 97:8(e9962) Received: 29 August 2017 / Received in final form: 30 December 2017 / Accepted: 30 January 2018 http://dx.doi.org/10.1097/MD.0000000000009962
Publisher Copyright:
© 2018 the Author(s). Published by Wolters Kluwer Health, Inc.
PY - 2018/2/1
Y1 - 2018/2/1
N2 - The aim of the present study was to investigate the age-related patterns and the relationships between serum levels of tartrate-resistant acid phosphatase-5b (TRACP-5b) or bone-specific alkaline phosphatase (BAP), and the heel stiffness index measured by quantitative ultrasound (QUS) in 429 Japanese men, with special emphasis on 2 age groups (40-59 years and 60 years or over). The heel stiffness index (bone mass) was measured by QUS. Serum samples were collected, and TRACP-5b and BAP levels were measured. The stiffness index was significantly decreased with age. Log (TRACP-5b) was significantly increased with age, but Log (BAP) was stable. Generalized linear models showed that higher levels of Log (TRACP-5b) and Log (BAP) were correlated with a lower stiffness index after adjusting for covariates in men aged 60 years or over, but not in men aged 40 to 59 years. In conclusion, higher rates of bone turnover markers were associated with a lower stiffness index only in elderly men. These results may indicate a different mechanism of low bone mass among different age groups of men.
AB - The aim of the present study was to investigate the age-related patterns and the relationships between serum levels of tartrate-resistant acid phosphatase-5b (TRACP-5b) or bone-specific alkaline phosphatase (BAP), and the heel stiffness index measured by quantitative ultrasound (QUS) in 429 Japanese men, with special emphasis on 2 age groups (40-59 years and 60 years or over). The heel stiffness index (bone mass) was measured by QUS. Serum samples were collected, and TRACP-5b and BAP levels were measured. The stiffness index was significantly decreased with age. Log (TRACP-5b) was significantly increased with age, but Log (BAP) was stable. Generalized linear models showed that higher levels of Log (TRACP-5b) and Log (BAP) were correlated with a lower stiffness index after adjusting for covariates in men aged 60 years or over, but not in men aged 40 to 59 years. In conclusion, higher rates of bone turnover markers were associated with a lower stiffness index only in elderly men. These results may indicate a different mechanism of low bone mass among different age groups of men.
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U2 - 10.1097/MD.0000000000009962
DO - 10.1097/MD.0000000000009962
M3 - Article
C2 - 29465590
AN - SCOPUS:85042499567
VL - 97
JO - Medicine; analytical reviews of general medicine, neurology, psychiatry, dermatology, and pediatries
JF - Medicine; analytical reviews of general medicine, neurology, psychiatry, dermatology, and pediatries
SN - 0025-7974
IS - 8
M1 - e9962
ER -