抄録
Whether the diurnal rhythm of cell cycle is associated with that of interferon-α/β receptor (IFNAR) expression was investigated in implanted-tumor cells. The expression of IFNAR mRNA significantly increased when the proportion of tumor cells in DNA synthesis (S) phase increased in vitro. A diurnal rhythm was observed for cell cycle distribution in implanted-tumor cells. The specific binding of interferon-α to receptor and IFNAR mRNA increased when the proportion of tumor cells in S phase increased in vivo. The time-dependent expression of IFNAR was supported by that of transcription factor level induced by interferon-β. The present result suggests that the rhythm of IFNAR expression is closely related to that of cell cycle distribution in implanted-tumor cells.
| 本文言語 | 英語 |
|---|---|
| ページ（範囲） | 1449-1455 |
| ページ数 | 7 |
| ジャーナル | Life Sciences |
| 巻 | 68 |
| 号 | 12 |
| DOI | |
| 出版ステータス | 出版済み - 2 9 2001 |
All Science Journal Classification (ASJC) codes
- 生化学、遺伝学、分子生物学（全般）
- 薬理学、毒性学および薬学（全般）