抄録
Whether the diurnal rhythm of cell cycle is associated with that of interferon-α/β receptor (IFNAR) expression was investigated in implanted-tumor cells. The expression of IFNAR mRNA significantly increased when the proportion of tumor cells in DNA synthesis (S) phase increased in vitro. A diurnal rhythm was observed for cell cycle distribution in implanted-tumor cells. The specific binding of interferon-α to receptor and IFNAR mRNA increased when the proportion of tumor cells in S phase increased in vivo. The time-dependent expression of IFNAR was supported by that of transcription factor level induced by interferon-β. The present result suggests that the rhythm of IFNAR expression is closely related to that of cell cycle distribution in implanted-tumor cells.
本文言語 | 英語 |
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ページ(範囲) | 1449-1455 |
ページ数 | 7 |
ジャーナル | Life Sciences |
巻 | 68 |
号 | 12 |
DOI | |
出版ステータス | 出版済み - 2月 9 2001 |
!!!All Science Journal Classification (ASJC) codes
- 生化学、遺伝学、分子生物学(全般)
- 薬理学、毒性学および薬学(全般)