Relationship between diurnal rhythm of cell cycle and interferon receptor expression in implanted-tumor cells

Hiroshi Takane, Shigehiro Ohdo, Tomoko Yamada, Satoru Koyanagi, Eiji Yukawa, Shun Higuchi

研究成果: Contribution to journalArticle査読

7 被引用数 (Scopus)

抄録

Whether the diurnal rhythm of cell cycle is associated with that of interferon-α/β receptor (IFNAR) expression was investigated in implanted-tumor cells. The expression of IFNAR mRNA significantly increased when the proportion of tumor cells in DNA synthesis (S) phase increased in vitro. A diurnal rhythm was observed for cell cycle distribution in implanted-tumor cells. The specific binding of interferon-α to receptor and IFNAR mRNA increased when the proportion of tumor cells in S phase increased in vivo. The time-dependent expression of IFNAR was supported by that of transcription factor level induced by interferon-β. The present result suggests that the rhythm of IFNAR expression is closely related to that of cell cycle distribution in implanted-tumor cells.

本文言語英語
ページ(範囲)1449-1455
ページ数7
ジャーナルLife Sciences
68
12
DOI
出版ステータス出版済み - 2 9 2001

All Science Journal Classification (ASJC) codes

  • 生化学、遺伝学、分子生物学(全般)
  • 薬理学、毒性学および薬学(全般)

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