Relationship between dynamic stress field and ECM production in regenerated cartilage tissue

Keisuke Fukuda, Yoshifumi Shigyo, Hideaki Ariura, Seiji Omata, Takehiro Morita, Tetsuo Yamaguchi, Yoshinori Sawae

    研究成果: Chapter in Book/Report/Conference proceedingConference contribution

    2 被引用数 (Scopus)

    抄録

    Mechanical stresses exerted in articular cartilage during daily joint movements can stimulate the metabolism of chondrocytes in cartilage. Upregulative effects of mechanical stimuli on extracellular matrix (ECM) biosynthesis of chondrocytes have been utilized in the cartilage tissue for regenerative tissue engineering. However, dynamic functionalities of these regenerated cartilages were lacked compared with the natural arthrodial cartilage. Natural synovial joint surfaces are contacting and sliding each other. As a result, the loading condition applied to the cartilage tissue is not simple. Under the contact between surfaces, non-uniform stress distribution is exerted in the cartilage tissue. The shear stress at contact area is highly depended on the distance from the surface. Moreover, the surface region is exposed to larger shear stress compared with the deep region. We hypothesized that high stress in surface region may stimulate chondrocytes selectively and establish anisotropic structure in elaborated tissue. In this study, the relative motion between cartilage surfaces in a synovial joint is simulated by the rolling-sliding motion of the roller on the cultured chondrocyte-agarose construct. Then, we investigated effects on the ECM distribution and morphology of regenerated cartilage tissue.

    本文言語英語
    ホスト出版物のタイトル2016 International Symposium on Micro-NanoMechatronics and Human Science, MHS 2016
    出版社Institute of Electrical and Electronics Engineers Inc.
    ISBN(電子版)9781509027842
    DOI
    出版ステータス出版済み - 1 18 2017
    イベント27th International Symposium on Micro-NanoMechatronics and Human Science, MHS 2016 - Nagoya, 日本
    継続期間: 11 28 201611 30 2016

    出版物シリーズ

    名前2016 International Symposium on Micro-NanoMechatronics and Human Science, MHS 2016

    その他

    その他27th International Symposium on Micro-NanoMechatronics and Human Science, MHS 2016
    国/地域日本
    CityNagoya
    Period11/28/1611/30/16

    All Science Journal Classification (ASJC) codes

    • 医学(その他)
    • 生体医工学
    • 機械工学
    • 人間とコンピュータの相互作用
    • 器械工学
    • コンピュータ サイエンスの応用
    • バイオテクノロジー
    • 人工知能

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