Relationship between dynamic stress field and ECM production in regenerated cartilage tissue

Keisuke Fukuda, Yoshifumi Shigyo, Hideaki Ariura, Seiji Omata, Takehiro Morita, Tetsuo Yamaguchi, Yoshinori Sawae

研究成果: 著書/レポートタイプへの貢献会議での発言

抄録

Mechanical stresses exerted in articular cartilage during daily joint movements can stimulate the metabolism of chondrocytes in cartilage. Upregulative effects of mechanical stimuli on extracellular matrix (ECM) biosynthesis of chondrocytes have been utilized in the cartilage tissue for regenerative tissue engineering. However, dynamic functionalities of these regenerated cartilages were lacked compared with the natural arthrodial cartilage. Natural synovial joint surfaces are contacting and sliding each other. As a result, the loading condition applied to the cartilage tissue is not simple. Under the contact between surfaces, non-uniform stress distribution is exerted in the cartilage tissue. The shear stress at contact area is highly depended on the distance from the surface. Moreover, the surface region is exposed to larger shear stress compared with the deep region. We hypothesized that high stress in surface region may stimulate chondrocytes selectively and establish anisotropic structure in elaborated tissue. In this study, the relative motion between cartilage surfaces in a synovial joint is simulated by the rolling-sliding motion of the roller on the cultured chondrocyte-agarose construct. Then, we investigated effects on the ECM distribution and morphology of regenerated cartilage tissue.

元の言語英語
ホスト出版物のタイトル2016 International Symposium on Micro-NanoMechatronics and Human Science, MHS 2016
出版者Institute of Electrical and Electronics Engineers Inc.
ISBN(電子版)9781509027842
DOI
出版物ステータス出版済み - 1 18 2017
イベント27th International Symposium on Micro-NanoMechatronics and Human Science, MHS 2016 - Nagoya, 日本
継続期間: 11 28 201611 30 2016

その他

その他27th International Symposium on Micro-NanoMechatronics and Human Science, MHS 2016
日本
Nagoya
期間11/28/1611/30/16

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cartilage
Cartilage
stress distribution
Extracellular Matrix
Tissue
matrices
Chondrocytes
Joints
shear stress
sliding
Shear stress
Mechanical Stress
Articular Cartilage
biosynthesis
rollers
Tissue Engineering
tissue engineering
Biosynthesis
metabolism
Sepharose

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Biomedical Engineering
  • Mechanical Engineering
  • Human-Computer Interaction
  • Instrumentation
  • Computer Science Applications
  • Biotechnology
  • Artificial Intelligence

これを引用

Fukuda, K., Shigyo, Y., Ariura, H., Omata, S., Morita, T., Yamaguchi, T., & Sawae, Y. (2017). Relationship between dynamic stress field and ECM production in regenerated cartilage tissue. : 2016 International Symposium on Micro-NanoMechatronics and Human Science, MHS 2016 [7824183] Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/MHS.2016.7824183

Relationship between dynamic stress field and ECM production in regenerated cartilage tissue. / Fukuda, Keisuke; Shigyo, Yoshifumi; Ariura, Hideaki; Omata, Seiji; Morita, Takehiro; Yamaguchi, Tetsuo; Sawae, Yoshinori.

2016 International Symposium on Micro-NanoMechatronics and Human Science, MHS 2016. Institute of Electrical and Electronics Engineers Inc., 2017. 7824183.

研究成果: 著書/レポートタイプへの貢献会議での発言

Fukuda, K, Shigyo, Y, Ariura, H, Omata, S, Morita, T, Yamaguchi, T & Sawae, Y 2017, Relationship between dynamic stress field and ECM production in regenerated cartilage tissue. : 2016 International Symposium on Micro-NanoMechatronics and Human Science, MHS 2016., 7824183, Institute of Electrical and Electronics Engineers Inc., 27th International Symposium on Micro-NanoMechatronics and Human Science, MHS 2016, Nagoya, 日本, 11/28/16. https://doi.org/10.1109/MHS.2016.7824183
Fukuda K, Shigyo Y, Ariura H, Omata S, Morita T, Yamaguchi T その他. Relationship between dynamic stress field and ECM production in regenerated cartilage tissue. : 2016 International Symposium on Micro-NanoMechatronics and Human Science, MHS 2016. Institute of Electrical and Electronics Engineers Inc. 2017. 7824183 https://doi.org/10.1109/MHS.2016.7824183
Fukuda, Keisuke ; Shigyo, Yoshifumi ; Ariura, Hideaki ; Omata, Seiji ; Morita, Takehiro ; Yamaguchi, Tetsuo ; Sawae, Yoshinori. / Relationship between dynamic stress field and ECM production in regenerated cartilage tissue. 2016 International Symposium on Micro-NanoMechatronics and Human Science, MHS 2016. Institute of Electrical and Electronics Engineers Inc., 2017.
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