Relationship between impaired cardiac sympathetic activity and spatial dyssynchrony in patients with non-ischemic heart failure: Assessment by MIBG scintigraphy and tagged MRI

Masato Yonezawa, Michinobu Nagao, Koichiro Abe, Yoshio Matsuo, Shingo Baba, Takeshi Kamitani, Takuro Isoda, Yasuhiro Maruoka, Mikako Jinnouchi, Yuzo Yamasaki, Kohtaro Abe, Taiki Higo, Takashi Yoshiura, Hiroshi Honda

研究成果: Contribution to journalArticle査読

8 被引用数 (Scopus)

抄録

Background: Impairment of cardiac sympathetic activity has various detrimental effects on cardiac function. The purpose was to investigate the relationship between left ventricular (LV) dyssynchrony and cardiac sympathetic activity in non-ischemic heart failure (HF). Methods: Twenty-seven patients with non-ischemic HF were enrolled. Cardiac sympathetic activity was assessed by heart-to-mediastinum ratio (H/M ratio) on 123I- Metaiodobenzylguanidine scintigraphy. LV dyssynchrony was assessed by cross-correlation analysis of time curves of myocardial circumferential strains delivered from cine-tagging MR images. Temporal dyssynchrony was defined as contraction delay between septal and lateral segments >110 milliseconds. Spatial dyssynchrony was defined as the negative value of the maximum correlation for the two strain time curves. Results: H/M ratio was significantly lower for patients with spatial dyssynchrony compared to patients without (1.8 ± 0.3 vs 2.1 ± 0.3, P <.05). There was no difference between patients with and without temporal dyssynchrony (2.0 ± 0.2 vs 2.0 ± 0.3). The incidence of spatial dyssynchrony was significantly higher in patients with H/M ratio <2.0 than those whose ratios were ≥2.0 (75% vs 20%, P =.001). There was no difference in the incidence of temporal dyssynchrony between the two groups (17% vs 20%). Conclusion: Impairment of cardiac sympathetic activity was found to be associated with spatial dyssynchrony in patients with non-ischemic HF.

本文言語英語
ページ(範囲)600-608
ページ数9
ジャーナルJournal of Nuclear Cardiology
20
4
DOI
出版ステータス出版済み - 8 2013

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine

フィンガープリント 「Relationship between impaired cardiac sympathetic activity and spatial dyssynchrony in patients with non-ischemic heart failure: Assessment by MIBG scintigraphy and tagged MRI」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル