Relationship between normal serum creatinine concentration and periodontal disease in japanese middle-aged males

Yoshihiro Shimazaki, Mitoshi Kushiyama, Masatoshi Murakami, Yoshihisa Yamashita

研究成果: Contribution to journalArticle査読

3 被引用数 (Scopus)

抄録

Background: Periodontitis has been shown to be closely related to diabetes, which was recently found to be associated with lower serum creatinine. Conversely, several studies have suggested a positive relationship between periodontitis and abnormally high concentrations of serum creatinine associated with renal dysfunction, seemingly contradicting the above. This study evaluates periodontal status and serum levels of creatinine within the normal range to resolve this apparent contradiction. Methods:Acomprehensive health examination of 907 Japanese males, 49 to 59 years old, was performed from 2000 to 2002. A blood sample was collected from the antecubital vein after an overnight fast. The periodontal parameters were periodontal probing depth (PD) and clinical attachment loss (AL).We examined the association between serum creatinine concentration within the normal range and periodontal parameters. Results: Serum creatinine concentration within the normal range was inversely correlated with mean PD and mean AL. In multivariate linear regression analyses, every 0.1-mg/dL increment in serum creatinine concentration was associated with a 0.064-mm decrease in both mean PD and mean AL (P <0.05) after adjusting for confounding variables. Conclusion: This study finds a significant inverse association between normal serum creatinine concentration and periodontal disease.

本文言語英語
ページ(範囲)94-99
ページ数6
ジャーナルJournal of periodontology
84
1
DOI
出版ステータス出版済み - 1 2013

All Science Journal Classification (ASJC) codes

  • Periodontics

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