Relationships of left ventricular strain and strain rate to wall stress and their afterload dependency

Daisuke Murai, Satoshi Yamada, Taichi Hayashi, Kazunori Okada, Hisao Nishino, Masahiro Nakabachi, Shinobu Yokoyama, Ayumu Abe, Ayako Ichikawa, Kota Ono, Sanae Kaga, Hiroyuki Iwano, Taisei Mikami, Hiroyuki Tsutsui

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Whether and how left ventricular (LV) strain and strain rate correlate with wall stress is not known. Furthermore, it is not determined whether strain or strain rate is less dependent on the afterload. In 41 healthy young adults, LV global peak strain and systolic peak strain rate in the longitudinal direction (LS and LSR, respectively) and circumferential direction (CS and CSR, respectively) were measured layer-specifically using speckle tracking echocardiography (STE) before and during a handgrip exercise. Among all the points before and during the exercise, all the STE parameters significantly correlated linearly with wall stress (LS: r = −0.53, p < 0.01, LSR: r = −0.28, p < 0.05, CS in the inner layer: r = −0.72, p < 0.01, CSR in the inner layer: r = −0.47, p < 0.01). Strain more strongly correlated with wall stress than strain rate (r = −0.53 for LS vs. r = −0.28 for LSR, p < 0.05; r = −0.72 for CS vs. r = −0.47 for CSR in the inner layer, p < 0.05), whereas the interobserver variability was similar between strain and strain rate (longitudinal 6.2 vs. 5.2 %, inner circumferential 4.8 vs. 4.7 %, mid-circumferential 7.9 vs. 6.9 %, outer circumferential 10.4 vs. 9.7 %), indicating that the differences in correlation coefficients reflect those in afterload dependency. It was thus concluded that LV strain and strain rate linearly and inversely correlated with wall stress in the longitudinal and circumferential directions, and strain more strongly depended on afterload than did strain rate. Myocardial shortening should be evaluated based on the relationships between these parameters and wall stress.

元の言語英語
ページ(範囲)574-583
ページ数10
ジャーナルHeart and Vessels
32
発行部数5
DOI
出版物ステータス出版済み - 5 1 2017

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

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    Murai, D., Yamada, S., Hayashi, T., Okada, K., Nishino, H., Nakabachi, M., Yokoyama, S., Abe, A., Ichikawa, A., Ono, K., Kaga, S., Iwano, H., Mikami, T., & Tsutsui, H. (2017). Relationships of left ventricular strain and strain rate to wall stress and their afterload dependency. Heart and Vessels, 32(5), 574-583. https://doi.org/10.1007/s00380-016-0900-4