Renal sympathetic denervation in rats

Masahiro Eriguchi, Kazuhiko Tsuruya

研究成果: 書籍/レポート タイプへの寄稿

6 被引用数 (Scopus)

抄録

Experimental renal sympathetic denervation is a well-established technique. Classically, renal sympathetic denervation is achieved by dorsal rhizotomy. While more recently, direct renal sympathetic denervation is typically applied by stripping all visible renal nerve bundles followed by painting with a solution of 10 % phenol in ethanol to remove the remaining nerves. In clinical settings, a reliable marker of renal sympathetic denervation or renal sympathetic overactivity has not been established. However, in experimental models, successful renal sympathetic denervation is validated by a decrease in renal norepinephrine content levels. This facilitates the assessment of incomplete denervation by technical failure and reinnervation for long-term experimental models. In this chapter, we introduce comprehensive methods for direct renal sympathetic denervation and measurement of renal norepinephrine content levels.

本文言語英語
ホスト出版物のタイトルMethods in Molecular Biology
出版社Humana Press Inc.
ページ45-52
ページ数8
DOI
出版ステータス出版済み - 2016

出版物シリーズ

名前Methods in Molecular Biology
1397
ISSN(印刷版)1064-3745

!!!All Science Journal Classification (ASJC) codes

  • 分子生物学
  • 遺伝学

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