Reprogramming of gastrointestinal cancer cells

Dyah Laksmi Dewi, Hideshi Ishii, Naotsugu Haraguchi, Shimpei Nishikawa, Yoshihiro Kano, Takahito Fukusumi, Katsuya Ohta, Susumu Miyazaki, Miyuki Ozaki, Daisuke Sakai, Taroh Satoh, Hiroaki Nagano, Yuichiro Doki, Masaki Mori

研究成果: Contribution to journalReview article査読

10 被引用数 (Scopus)

抄録

Cell reprogramming reverts cells to multipotent, preprogrammed states by re-establishing epigenetic markers. It can also induce considerable malignant phenotype modification. Because key events in cancer relapse and metastasis, including epithelial-mesenchymal transition phenotypes, are regulated primarily by reversible and transient epigenetic modifications rather than the accumulation of irreversible and stable genetic abnormalities, studying dynamic mechanisms regulating these biological processes is important. Transcription factors for induced pluripotent stem cells and non-coding microRNAs allow pluripotent phenotype induction. We present the current knowledge of the possible applications of cell reprogramming in reducing aggressive phenotype expression, which can induce tumor cell hibernation and maintain appropriate phenotypes, thereby minimizing relapse and metastasis after surgical resection of gastrointestinal cancer.

本文言語英語
ページ(範囲)393-399
ページ数7
ジャーナルCancer Science
103
3
DOI
出版ステータス出版済み - 2012

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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