Requirement for CD8 β chain in positive selection of CD8-lineage T cells

Kei Ichi Nakayama, Keiko Nakayama, Izumi Negishi, Keisuke Kuida, Marjorie C. Louie, Osami Kanagawa, Hiromitsu Nakauchi, Dennis Y. Loh

研究成果: Contribution to journalArticle査読

110 被引用数 (Scopus)

抄録

CD8 is either an αα homodimer or an αβ heterodimer, although most peripheral CD8-lineage T cells express only the CD8αβ heterodimer. The physiological function of CD8β was elucidated with mice that were chimeric for the homozygous disruption of the CD8β gene. The CD8β-/- T cells developed normally to CD4+CD8 + stage, but did not efficiently differentiate further, which resulted in few peripheral CD8+ T cells. The number of peripheral CD8+ T cells was restored by transfer of an exogenous CD8β gene into CD8β-deficient T cells. Thus, CD8β is necessary for the maturation of CD8+ T cells.

本文言語英語
ページ(範囲)1131-1133
ページ数3
ジャーナルScience
263
5150
DOI
出版ステータス出版済み - 1994
外部発表はい

All Science Journal Classification (ASJC) codes

  • General

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