Resetting the Epigenome beyond Pluripotency in the Germline

Katsuhiko Hayashi, M. Azim Surani

研究成果: Contribution to journalReview article査読

72 被引用数 (Scopus)

抄録

Germ cells undergo comprehensive epigenetic reprogramming toward acquiring fitness for pluripotency and totipotency. Notably, the full extent of the epigenetic reprogramming experienced by germ cells remains unmatched by attempts to experimentally restore pluripotency in somatic cells. We propose that the defects present in experimentally generated cells are corrected upon differentiation into the germ cell lineage, as has been observed in cases of germline transmission. Unraveling the mechanisms responsible for germ cell-specific epigenetic reprogramming will likely have important implications for both basic and clinical stem cell research.

本文言語英語
ページ(範囲)493-498
ページ数6
ジャーナルCell stem cell
4
6
DOI
出版ステータス出版済み - 6 5 2009
外部発表はい

All Science Journal Classification (ASJC) codes

  • 分子医療
  • 遺伝学
  • 細胞生物学

フィンガープリント

「Resetting the Epigenome beyond Pluripotency in the Germline」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル