Resistance to pseudorabies virus infection in transformed cell lines expressing a soluble form of porcine herpesvirus entry mediator C

Etsuro Ono, Keiko Amagai, Saori Yoshino, Satoshi Taharaguchi, Manabu Inobe, Toshimitsu Uede

研究成果: Contribution to journalArticle査読

14 被引用数 (Scopus)

抄録

Porcine herpesvirus entry mediator C (HveC) is an alphaherpesvirus receptor that binds to virion glycoprotein D (gD). Porcine HveC mediates entry of pseudorabies virus (PRV), herpes simplex virus types 1 and 2 (HSV-1 and HSV-2) and bovine herpesvirus type 1 (BHV-1). In order to assess the antiviral potential of a soluble form of porcine HveC, Vero cells were transformed with the chimeric gene expressing a fusion protein (PHveClg) consisting of an extracellular domain of porcine HveC and the Fc portion of human IgG1. The transformed cell lines expressing PHveClg showed marked resistance to PRV infection. Resistance to infection by other alphaherpesviruses (HSV-1 and BHV-1) was also observed in the transformed cell line. The present results demonstrate that a soluble form of porcine HveC is able to exert a significant antiviral effect against pseudorabies virus and other alphaherpesvirus infection in vitro.

本文言語英語
ページ(範囲)173-178
ページ数6
ジャーナルJournal of General Virology
85
1
DOI
出版ステータス出版済み - 1 2004
外部発表はい

All Science Journal Classification (ASJC) codes

  • ウイルス学

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