Respiratory involvement and immune status in Yusho patients

Yoichi Nakanishi, N. Shigematsu, Y. Kurita

研究成果: ジャーナルへの寄稿記事

75 引用 (Scopus)

抄録

Clinical and experimental studies on respiratory involvement and alterations in immune status were carried out. Respiratory distress occurring in these patients has improved gradually for 14 years but still remains. Copious expectoration at an eary stage of the disease may be related to the fact that a number of discrete polychlorinated biphenyls (PCBs) are distributed throughout the lung parenchyma. For accumulation in the bronchial mucosa, structural requirements and specific dose dependence of PCBs have been clearly shown; however, pathological and physiological studies have indicated that respiratory involvement in Yusho is mainly small airway disease that may be caused by involvement of cellular component (Clara cells) in bronchioles and/or associated infection. Respiratory distress is often exacerbated by viral or bacterial infection. Changes in the immune status in PCB and polychlorinated dibenzofuran (PCDF) poisoning are as follows: IgA and IgM in the serum are decreased at an early stage of the disease and then return to normal; suppression of cellular immunity was reported in Taiwanese patients and some may remain in the later stages of the disease, as shown in our patients. PCDFs now appear to be the main causal agents in Yusho. Rats given PCDFs showed necrosis of the Clara cells in bronchioles and marked thymus atrophy, while few such changes were noted in rats given PCBs. Therefore, further examination is needed for the difference of the toxic effects between two compounds.

元の言語英語
ページ(範囲)31-36
ページ数6
ジャーナルEnvironmental Health Perspectives
VOL
発行部数59
出版物ステータス出版済み - 1 1 1985

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Polychlorinated Biphenyls
Bronchioles
Poisons
Virus Diseases
Cellular Structures
Bacterial Infections
Cellular Immunity
Poisoning
Immunoglobulin A
Thymus Gland
Atrophy
Immunoglobulin M
Mucous Membrane
Necrosis
Lung
Infection
Serum

All Science Journal Classification (ASJC) codes

  • Public Health, Environmental and Occupational Health
  • Health, Toxicology and Mutagenesis

これを引用

Nakanishi, Y., Shigematsu, N., & Kurita, Y. (1985). Respiratory involvement and immune status in Yusho patients. Environmental Health Perspectives, VOL(59), 31-36.

Respiratory involvement and immune status in Yusho patients. / Nakanishi, Yoichi; Shigematsu, N.; Kurita, Y.

:: Environmental Health Perspectives, 巻 VOL, 番号 59, 01.01.1985, p. 31-36.

研究成果: ジャーナルへの寄稿記事

Nakanishi, Y, Shigematsu, N & Kurita, Y 1985, 'Respiratory involvement and immune status in Yusho patients', Environmental Health Perspectives, 巻. VOL, 番号 59, pp. 31-36.
Nakanishi Y, Shigematsu N, Kurita Y. Respiratory involvement and immune status in Yusho patients. Environmental Health Perspectives. 1985 1 1;VOL(59):31-36.
Nakanishi, Yoichi ; Shigematsu, N. ; Kurita, Y. / Respiratory involvement and immune status in Yusho patients. :: Environmental Health Perspectives. 1985 ; 巻 VOL, 番号 59. pp. 31-36.
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