Response regulator YycF essential for bacterial growth: X-ray crystal structure of the DNA-binding domain and its PhoB-like DNA recognition motif

Toshihide Okajima, Akihiro Doi, Ario Okada, Yasuhiro Gotoh, Katsuyuki Tanizawa, Ryutaro Utsumi

研究成果: ジャーナルへの寄稿学術誌査読

19 被引用数 (Scopus)

抄録

A response regulator YycF and its cognate sensor kinase YycG constitute the two-component signal transduction system essential for growth of Gram-positive bacteria with a low GC content. We have determined the X-ray crystal structure of the effector domain of Bacillus subtilis YycF involved in DNA binding. The structure, containing a winged helix-turn-helix motif, was found to be very similar to that of the response regulator PhoB from Escherichia coli. Specific binding of YycF to the PhoB-regulated alkaline phosphatase promoter was also demonstrated.

本文言語英語
ページ(範囲)3434-3438
ページ数5
ジャーナルFEBS Letters
582
23-24
DOI
出版ステータス出版済み - 10月 15 2008
外部発表はい

!!!All Science Journal Classification (ASJC) codes

  • 生物理学
  • 構造生物学
  • 生化学
  • 分子生物学
  • 遺伝学
  • 細胞生物学

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