Responses of adrenal catecholamine secretion to lateral hypothalamic stimulation and lesion in rats

Toshihiko Katafuchi, Hironobu Yoshimatsu, Yutaka Oomura, Akio Sato

研究成果: ジャーナルへの寄稿記事

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The effects of electrical stimulation and lesion of the lateral hypothalamic area (LHA) on catecholamine (CA) secretion from the adrenal medulla were investigated in anesthetized rats. A differential secretion of epinephrine (E) and norepinephrine (NE) was observed, in which a single stimulating site could produce different effects on E and NE secretion. On the basis of change in the E secretion rate during stimulation, stimulation sites could be classified into 3 groups: group A which showed increase in E secretion (no change in NE), group B which showed decrease in E (and also decrease in NE), and group C which showed no change in E (but a decrease in NE). No relationship was observed between the sites of stimulation in the LHA and the direction of the responses. Lesions of the stimulation sites decreased CA secretion to different extent among the three groups and these differences could be predicted by the effects of stimulation at the same sites. These results suggest that the LHA has both facilitatory and inhibitory effects on the sympatho-adrenal function and that the former is predominant.

元の言語英語
ページ(範囲)141-144
ページ数4
ジャーナルBrain Research
363
発行部数1
DOI
出版物ステータス出版済み - 1 15 1986

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All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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