Responses of the pigmented rabbit retina to NMPTP, a chemical inducer of Parkinsonism

Corinne Wong, Tatsuro Ishibashi, Gail Tucker, Duco Hamasaki

研究成果: ジャーナルへの寄稿記事

28 引用 (Scopus)

抄録

The electrophysiological and neurochemical effects of N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (NMPTP), a chemical inducer of Parkinsonism in man and monkeys, on the pigmented rabbit retina were determined under both chronic and acute conditions. The implicit time, the oscillatory potentials, and the amplitude of the b-wave of the rabbit electroretinogram were affected; both dopamine and dihydroxyphenylalanine (DOPA) levels were depressed. Ultrastructural analysis of acute and chronic retinas showed the occurrence of an intranuclear filamentous inclusion in the nucleus of some cells in the inner nuclear and ganglion cell layer of chronic samples. The effects of the neurotoxin NMPTP on the retina suggest that dopaminergic metabolism is impaired, which then affects the components of the electroretinogram attributed to both bipolar and amacrine cells. In addition, the retina may provide a model in which to study the bichemical and pharmacological mechanisms of NMPTP toxicity.

元の言語英語
ページ(範囲)509-519
ページ数11
ジャーナルExperimental Eye Research
40
発行部数4
DOI
出版物ステータス出版済み - 1 1 1985
外部発表Yes

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1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
Parkinsonian Disorders
Retina
Rabbits
Amacrine Cells
Intranuclear Inclusion Bodies
Dihydroxyphenylalanine
Neurotoxins
Cell Nucleus
Ganglia
Haplorhini
Dopamine
Pharmacology

All Science Journal Classification (ASJC) codes

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience

これを引用

Responses of the pigmented rabbit retina to NMPTP, a chemical inducer of Parkinsonism. / Wong, Corinne; Ishibashi, Tatsuro; Tucker, Gail; Hamasaki, Duco.

:: Experimental Eye Research, 巻 40, 番号 4, 01.01.1985, p. 509-519.

研究成果: ジャーナルへの寄稿記事

Wong, Corinne ; Ishibashi, Tatsuro ; Tucker, Gail ; Hamasaki, Duco. / Responses of the pigmented rabbit retina to NMPTP, a chemical inducer of Parkinsonism. :: Experimental Eye Research. 1985 ; 巻 40, 番号 4. pp. 509-519.
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