Restoration of microglial function by granulocyte-colony stimulating factor in ALS model mice

Ryo Yamasaki, Masahito Tanaka, Mami Fukunaga, Takahisa Tateishi, Hitoshi Kikuchi, Kyoko Motomura, Takuya Matsushita, Yasumasa Ohyagi, Jun-Ichi Kira

研究成果: ジャーナルへの寄稿記事

29 引用 (Scopus)

抄録

We studied the effects of G-CSF on microglial reactions in mutant SOD1 (mSOD1)-Tg (G93A) ALS model mice. Following hypoglossal axotomy, the numbers of neurons and microglia expressing GDNF were significantly lower in mSOD1-Tg mice than in non-transgenic (NTG) littermates. This decrease in the number of neurons after axotomy and a decrease in the number of large myelinated axons in mSOD1-Tg mice over the disease course were improved by G-CSF, which also increased microglial recruitment. Impaired migration of cultured mSOD1-Tg microglia to MCP-1 was recovered following G-CSF treatment. Restoration of microglial responses by G-CSF may contribute to its neuroprotective effects.

元の言語英語
ページ(範囲)51-62
ページ数12
ジャーナルJournal of Neuroimmunology
229
発行部数1-2
DOI
出版物ステータス出版済み - 12 15 2010

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Granulocyte Colony-Stimulating Factor
Axotomy
Microglia
Glial Cell Line-Derived Neurotrophic Factor
Neurons
Neuroprotective Agents
Axons

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology
  • Neurology
  • Clinical Neurology

これを引用

Restoration of microglial function by granulocyte-colony stimulating factor in ALS model mice. / Yamasaki, Ryo; Tanaka, Masahito; Fukunaga, Mami; Tateishi, Takahisa; Kikuchi, Hitoshi; Motomura, Kyoko; Matsushita, Takuya; Ohyagi, Yasumasa; Kira, Jun-Ichi.

:: Journal of Neuroimmunology, 巻 229, 番号 1-2, 15.12.2010, p. 51-62.

研究成果: ジャーナルへの寄稿記事

Yamasaki, Ryo ; Tanaka, Masahito ; Fukunaga, Mami ; Tateishi, Takahisa ; Kikuchi, Hitoshi ; Motomura, Kyoko ; Matsushita, Takuya ; Ohyagi, Yasumasa ; Kira, Jun-Ichi. / Restoration of microglial function by granulocyte-colony stimulating factor in ALS model mice. :: Journal of Neuroimmunology. 2010 ; 巻 229, 番号 1-2. pp. 51-62.
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AU - Kikuchi, Hitoshi

AU - Motomura, Kyoko

AU - Matsushita, Takuya

AU - Ohyagi, Yasumasa

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