Restorative effects of human neural stem cell grafts on the primate spinal cord

Ephron S. Rosenzweig, John H. Brock, Paul Lu, Hiromi Kumamaru, Ernesto A. Salegio, Ken Kadoya, Janet L. Weber, Justine J. Liang, Rod Moseanko, Stephanie Hawbecker, J. Russell Huie, Leif A. Havton, Yvette S. Nout-Lomas, Adam R. Ferguson, Michael S. Beattie, Jacqueline C. Bresnahan, Mark H. Tuszynski

研究成果: Contribution to journalArticle

86 引用 (Scopus)

抜粋

We grafted human spinal cord-derived neural progenitor cells (NPCs) into sites of cervical spinal cord injury in rhesus monkeys (Macaca mulatta). Under three-drug immunosuppression, grafts survived at least 9 months postinjury and expressed both neuronal and glial markers. Monkey axons regenerated into grafts and formed synapses. Hundreds of thousands of human axons extended out from grafts through monkey white matter and synapsed in distal gray matter. Grafts gradually matured over 9 months and improved forelimb function beginning several months after grafting. These findings in a 'preclinical trial' support translation of NPC graft therapy to humans with the objective of reconstituting both a neuronal and glial milieu in the site of spinal cord injury.

元の言語英語
ページ(範囲)484-490
ページ数7
ジャーナルNature medicine
24
発行部数4
DOI
出版物ステータス出版済み - 5 1 2018

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)

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    Rosenzweig, E. S., Brock, J. H., Lu, P., Kumamaru, H., Salegio, E. A., Kadoya, K., Weber, J. L., Liang, J. J., Moseanko, R., Hawbecker, S., Huie, J. R., Havton, L. A., Nout-Lomas, Y. S., Ferguson, A. R., Beattie, M. S., Bresnahan, J. C., & Tuszynski, M. H. (2018). Restorative effects of human neural stem cell grafts on the primate spinal cord. Nature medicine, 24(4), 484-490. https://doi.org/10.1038/nm.4502