Restraint stress-induced elevation of endogenous glucocorticoids decreases Peyer's patch cell numbers via mechanisms that are either dependent or independent on apoptotic cell death

Nobuyuki Sudo, Naomi Oyama, Xiao Nian Yu, Chiharu Kubo

研究成果: ジャーナルへの寄稿学術誌査読

16 被引用数 (Scopus)

抄録

In this study, we investigated whether restraint stress induces either apoptotic cell death or lymphocyte migration in Peyer's patches. Exposure to stress induced a striking decrease in the number of CD3+CD4+, CD3+CD8+ and B220+ cells. Such decreases were accompanied by the enhanced induction of apoptosis in Peyer's patches. The apoptosis of Peyer's patch cells was completely reversed by pretreatment with either high or low doses of RU-486, a glucocorticoid receptor antagonist. In contrast, the stress-induced lymphopenia was little affected by administration of low doses of RU-486, although such lymphopenia was perfectly inhibited by treatment with high doses of RU-486. Taken together, these results suggest that the stress-induced lymphopenia in Peyer's patches is partly due to apoptotic cell death, although other systems such as lymphocyte migration, may contribute to such a reduction in the number of Peyer's patch cells.

本文言語英語
ページ(範囲)333-339
ページ数7
ジャーナルNeuroImmunoModulation
9
6
DOI
出版ステータス出版済み - 2001

!!!All Science Journal Classification (ASJC) codes

  • 免疫学
  • 内分泌学
  • 神経学
  • 内分泌系および自律システム

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