Restricted microbiota and absence of cognate TCR antigen leads to an unbalanced generation of Th17 cells

Matthias Lochner, Marion Bérard, Shinichiro Sawa, Siona Hauer, Valérie Gaboriau-Routhiau, Tahia Diana Fernandez, Johannes Snel, Philippe Bousso, Nadine Cerf-Bensussan, Gérard Eberl

研究成果: ジャーナルへの寄稿記事

57 引用 (Scopus)

抜粋

Retinoic acid-related orphan receptor (ROR)γt+ TCRαβ+ cells expressing IL-17, termed Th17 cells, are most abundant in the intestinal lamina propria. Symbiotic microbiota are required for the generation of Th17 cells, but the requirement for microbiota-derived Ag is not documented. In this study, we show that normal numbers of Th17 cells develop in the intestine of mice that express a single TCR in the absence of cognate Ag, whereas the microbiota remains essential for their development. However, such mice, or mice monocolonized with the Th17-inducing segmented filamentous bacteria, fail to induce normal numbers of Foxp3+ RORγt+ T cells, the regulatory counterpart of IL-17 +RORγt+ T cells. These results demonstrate that a complex microbiota and cognate Ag are required to generate a properly regulated set of RORγt+ T cells and Th17 cells.

元の言語英語
ページ(範囲)1531-1537
ページ数7
ジャーナルJournal of Immunology
186
発行部数3
DOI
出版物ステータス出版済み - 2 1 2011
外部発表Yes

    フィンガープリント

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology

これを引用

Lochner, M., Bérard, M., Sawa, S., Hauer, S., Gaboriau-Routhiau, V., Fernandez, T. D., ... Eberl, G. (2011). Restricted microbiota and absence of cognate TCR antigen leads to an unbalanced generation of Th17 cells. Journal of Immunology, 186(3), 1531-1537. https://doi.org/10.4049/jimmunol.1001723