Resveratrol attenuates angiotensin II-induced senescence of vascular smooth muscle cells

Toshihiro Ichiki, Ryohei Miyazaki, Aya Kamiharaguchi, Toru Hashimoto, Hirohide Matsuura, Shiro Kitamoto, Tomotake Tokunou, Kenji Sunagawa

研究成果: Contribution to journalArticle査読

13 被引用数 (Scopus)

抄録

Resveratrol (3,5,4'-trihydroxystilbene), a polyphenol abundant in red wine, is known to extend the life span of diverse species. On the contrary, it was reported that angiotensin (Ang) II enhances senescence of vascular smooth muscle cells (VSMCs). We, therefore, examined whether resveratrol attenuates Ang II-induced senescence of VSMC. Senescence-associated β-galactosidase (SA β-gal) assay showed that Ang II induced senescence of VSMC. The Ang II-induced senescence was inhibited by losartan, an Ang II type 1 receptor (AT1R) antagonist but not by PD123319, Ang II type 2 receptor antagonist, indicating that AT1R is responsible for the induction of senescence. Resveratrol suppressed Ang II-induced senescence of VSMC in a dose-dependent manner. In addition, resveratrol suppressed Ang II-induced induction of p53 and its downstream target gene p21, both of which play an important role in the induction of senescence. Resveratrol suppressed senescence of VSMC possibly through inhibition of AT1R-dependent induction of p53/p21. Suppression of p53 induction may be involved in the longevity by resveratrol.

本文言語英語
ページ(範囲)35-39
ページ数5
ジャーナルRegulatory Peptides
177
1-3
DOI
出版ステータス出版済み - 8 20 2012

All Science Journal Classification (ASJC) codes

  • 生化学
  • 生理学
  • 内分泌学
  • 臨床生化学
  • 細胞および分子神経科学

フィンガープリント

「Resveratrol attenuates angiotensin II-induced senescence of vascular smooth muscle cells」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル