Retinoic acid fails to reverse emphysema in adult mouse models

M. Fujita, Q. Ye, H. Ouchi, N. Nakashima, N. Hamada, N. Hagimoto, K. Kuwano, R. J. Mason, Y. Nakanishi

研究成果: Contribution to journalArticle

79 引用 (Scopus)

抜粋

Background: Previous work has shown that all-trans-retinoic acid reverses elastase induced emphysema in rats. Since there is currently no effective treatment for pulmonary emphysema, the effect of retinoic acid should be further investigated in other adult species. A study was undertaken using two murine models of emphysema to evaluate the effect of retinoic acid. Methods: The models used were an elastase induced emphysema model for acute alveolar destruction and a tumour necrosis factor (TNF)-α transgenic mouse which exhibits chronic air space enlargement, loss of elastic recoil, increased lung volume, and pulmonary hypertension comparable to human pulmonary emphysema. All-frans-retinoic acid (2 mg/kg) was injected for 12 successive days after the establishment of emphysema. The effects of treatment were evaluated using physiological and morphometric analyses. Results: In contrast to the rat, administration of all-trans-retinoic acid in these murine models did not improve the emphysema. Moreover, worsening of emphysema was observed in TNF-α transgenic mice treated with all-trans-retinoic acid. The level of keratinocyte chemoattractant (KC), a CXC chemokine, in bronchoalveolar lavage fluid was increased in TNF-α transgenic mice following retinoic acid treatment. These data raise the possibility that retinoic acid causes deterioration of emphysema by promoting inflammation in this model. Conclusions: In these models, retinoic acid did not show positive effects on emphysema. The effect of retinoic acid in the treatment of pulmonary emphysema remains controversial, and further studies are required to determine its physiological effects under a variety of experimental conditions.

元の言語英語
ページ(範囲)224-230
ページ数7
ジャーナルThorax
59
発行部数3
DOI
出版物ステータス出版済み - 3 2004

All Science Journal Classification (ASJC) codes

  • Pulmonary and Respiratory Medicine

フィンガープリント Retinoic acid fails to reverse emphysema in adult mouse models' の研究トピックを掘り下げます。これらはともに一意のフィンガープリントを構成します。

  • これを引用

    Fujita, M., Ye, Q., Ouchi, H., Nakashima, N., Hamada, N., Hagimoto, N., Kuwano, K., Mason, R. J., & Nakanishi, Y. (2004). Retinoic acid fails to reverse emphysema in adult mouse models. Thorax, 59(3), 224-230. https://doi.org/10.1136/thx.2003.010785