Reversible electrical breakdown of bilayer lipid membranes with a ramped voltage and the quantitative analysis based on a transient aqueous pore model

J. Suehiro, H. Fujinobu, M. Hara

研究成果: ジャーナルへの寄稿学術誌査読

抄録

Reversible electrical breakdown of bilayer lipid membranes is observed by using the voltage-clamp method with ramped voltage waveforms. It is shown experimentally that the critical transmembrane voltage at which membrane conductance drastically increases depends on the ramp rate. The pore growing process is discussed quantitatively based on a transient pore model of the breakdown phenomena. The comparison between the experimental results and theoretical prediction shows that the model can describe the time course of the pore development and resultant increase in the membrane conductance. Effects of the voltage rising rate on the electroporation and the membrane conductance increase are discussed by using the transient pore model. (from Authors)

本文言語英語
ページ(範囲)263-277
ページ数15
ジャーナルMemoirs - Kyushu University, Faculty of Engineering
54
4
出版ステータス出版済み - 1994

!!!All Science Journal Classification (ASJC) codes

  • エネルギー(全般)
  • 大気科学
  • 地球惑星科学(全般)
  • 技術マネージメントおよび技術革新管理

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