Review of chemotherapeutic approaches for operable and inoperable esophageal squamous cell carcinoma

Y. Baba, Hiroshi Saeki, Yuichiro Nakashima, Eiji Oki, H. Shigaki, N. Yoshida, M. Watanabe, Yoshihiko Maehara, Hideo Baba

研究成果: ジャーナルへの寄稿評論記事

12 引用 (Scopus)

抄録

The predominant histological types of esophageal cancer are adenocarcinoma and squamous cell carcinoma. Since these two histological types present as different diseases in terms of their epidemiology, pathologenesis, and tumor biology, separate therapeutic approaches should be developed against each type. While surgical resection remains the dominant therapeutic intervention for patients with operable esophageal squamous cell carcinoma (ESCC), their high rates of tumor recurrence have prompted investigation of multimodality therapies that combine surgery with chemotherapy, radiotherapy, and chemoradiotherapy. In Japan, preoperative chemotherapy with cisplatin (CDDP) plus 5-fluorouracil (5-FU) followed by radical esophagectomy has been accepted as the standard therapeutic approach for resactable clinical Stage II/III ESCC. Similarly, the CDDP and 5-FU regimen has been accepted as the first-line treatment for metastatic and unresectable ESCCs in Japan. Thus, in Japan chemotherapy is an indispensable component of therapy for both resectable and unresectable ESCCs. This review discusses the current knowledge, rationale, and available data regarding chemotherapy for resectable and unresectable ESCCs.

元の言語英語
記事番号12521
ジャーナルDiseases of the Esophagus
30
発行部数2
DOI
出版物ステータス出版済み - 2 1 2017

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Drug Therapy
Japan
Fluorouracil
Therapeutics
Esophagectomy
Chemoradiotherapy
Esophageal Neoplasms
Cisplatin
Esophageal Squamous Cell Carcinoma
Squamous Cell Carcinoma
Neoplasms
Epidemiology
Adenocarcinoma
Radiotherapy
Recurrence

All Science Journal Classification (ASJC) codes

  • Gastroenterology

これを引用

Review of chemotherapeutic approaches for operable and inoperable esophageal squamous cell carcinoma. / Baba, Y.; Saeki, Hiroshi; Nakashima, Yuichiro; Oki, Eiji; Shigaki, H.; Yoshida, N.; Watanabe, M.; Maehara, Yoshihiko; Baba, Hideo.

:: Diseases of the Esophagus, 巻 30, 番号 2, 12521, 01.02.2017.

研究成果: ジャーナルへの寄稿評論記事

Baba, Y. ; Saeki, Hiroshi ; Nakashima, Yuichiro ; Oki, Eiji ; Shigaki, H. ; Yoshida, N. ; Watanabe, M. ; Maehara, Yoshihiko ; Baba, Hideo. / Review of chemotherapeutic approaches for operable and inoperable esophageal squamous cell carcinoma. :: Diseases of the Esophagus. 2017 ; 巻 30, 番号 2.
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abstract = "The predominant histological types of esophageal cancer are adenocarcinoma and squamous cell carcinoma. Since these two histological types present as different diseases in terms of their epidemiology, pathologenesis, and tumor biology, separate therapeutic approaches should be developed against each type. While surgical resection remains the dominant therapeutic intervention for patients with operable esophageal squamous cell carcinoma (ESCC), their high rates of tumor recurrence have prompted investigation of multimodality therapies that combine surgery with chemotherapy, radiotherapy, and chemoradiotherapy. In Japan, preoperative chemotherapy with cisplatin (CDDP) plus 5-fluorouracil (5-FU) followed by radical esophagectomy has been accepted as the standard therapeutic approach for resactable clinical Stage II/III ESCC. Similarly, the CDDP and 5-FU regimen has been accepted as the first-line treatment for metastatic and unresectable ESCCs in Japan. Thus, in Japan chemotherapy is an indispensable component of therapy for both resectable and unresectable ESCCs. This review discusses the current knowledge, rationale, and available data regarding chemotherapy for resectable and unresectable ESCCs.",
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T1 - Review of chemotherapeutic approaches for operable and inoperable esophageal squamous cell carcinoma

AU - Baba, Y.

AU - Saeki, Hiroshi

AU - Nakashima, Yuichiro

AU - Oki, Eiji

AU - Shigaki, H.

AU - Yoshida, N.

AU - Watanabe, M.

AU - Maehara, Yoshihiko

AU - Baba, Hideo

PY - 2017/2/1

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N2 - The predominant histological types of esophageal cancer are adenocarcinoma and squamous cell carcinoma. Since these two histological types present as different diseases in terms of their epidemiology, pathologenesis, and tumor biology, separate therapeutic approaches should be developed against each type. While surgical resection remains the dominant therapeutic intervention for patients with operable esophageal squamous cell carcinoma (ESCC), their high rates of tumor recurrence have prompted investigation of multimodality therapies that combine surgery with chemotherapy, radiotherapy, and chemoradiotherapy. In Japan, preoperative chemotherapy with cisplatin (CDDP) plus 5-fluorouracil (5-FU) followed by radical esophagectomy has been accepted as the standard therapeutic approach for resactable clinical Stage II/III ESCC. Similarly, the CDDP and 5-FU regimen has been accepted as the first-line treatment for metastatic and unresectable ESCCs in Japan. Thus, in Japan chemotherapy is an indispensable component of therapy for both resectable and unresectable ESCCs. This review discusses the current knowledge, rationale, and available data regarding chemotherapy for resectable and unresectable ESCCs.

AB - The predominant histological types of esophageal cancer are adenocarcinoma and squamous cell carcinoma. Since these two histological types present as different diseases in terms of their epidemiology, pathologenesis, and tumor biology, separate therapeutic approaches should be developed against each type. While surgical resection remains the dominant therapeutic intervention for patients with operable esophageal squamous cell carcinoma (ESCC), their high rates of tumor recurrence have prompted investigation of multimodality therapies that combine surgery with chemotherapy, radiotherapy, and chemoradiotherapy. In Japan, preoperative chemotherapy with cisplatin (CDDP) plus 5-fluorouracil (5-FU) followed by radical esophagectomy has been accepted as the standard therapeutic approach for resactable clinical Stage II/III ESCC. Similarly, the CDDP and 5-FU regimen has been accepted as the first-line treatment for metastatic and unresectable ESCCs in Japan. Thus, in Japan chemotherapy is an indispensable component of therapy for both resectable and unresectable ESCCs. This review discusses the current knowledge, rationale, and available data regarding chemotherapy for resectable and unresectable ESCCs.

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