RF-NR: Random Forest Based Approach for Improved Classification of Nuclear Receptors

Hamid D. Ismail, Hiroto Saigo, Dukka B. Kc

研究成果: Contribution to journalArticle査読

3 被引用数 (Scopus)

抄録

The Nuclear Receptor (NR) superfamily plays an important role in key biological, developmental, and physiological processes. Developing a method for the classification of NR proteins is an important step towards understanding the structure and functions of the newly discovered NR protein. The recent studies on NR classification are either unable to achieve optimum accuracy or are not designed for all the known NR subfamilies. In this study, we developed RF-NR, which is a Random Forest based approach for improved classification of nuclear receptors. The RF-NR can predict whether a query protein sequence belongs to one of the eight NR subfamilies or it is a non-NR sequence. The RF-NR uses spectrum-like features namely: Amino Acid Composition, Di-peptide Composition, and Tripeptide Composition. Benchmarking on two independent datasets with varying sequence redundancy reduction criteria, the RF-NR achieves better (or comparable) accuracy than other existing methods. The added advantage of our approach is that we can also obtain biological insights about the important features that are required to classify NR subfamilies. RF-NR is freely available at http://bcb.ncat.edu/RF-NR/.

本文言語英語
論文番号8107505
ページ(範囲)1844-1852
ページ数9
ジャーナルIEEE/ACM Transactions on Computational Biology and Bioinformatics
15
6
DOI
出版ステータス出版済み - 11 1 2018

All Science Journal Classification (ASJC) codes

  • バイオテクノロジー
  • 遺伝学
  • 応用数学

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