Rho-kinase inhibitors from adlay seeds

Yhiya Amen, Qinchang Zhu, Hai Bang Tran, Mohamed S. Afifi, Ahmed F. Halim, Ahmed Ashour, Ryoji Fujimoto, Takahiro Goto, Kuniyoshi Shimizu

研究成果: ジャーナルへの寄稿記事

1 引用 (Scopus)

抄録

Rho-kinase enzymes are one of the most important targets recently identified in our bodies. Several lines of evidence indicate that these enzymes are involved in many diseases and cellular disorders. ROCK inhibitors may have clinical applications for cancer, hypertension, glaucoma, etc. Our study aims to identify the possible involvement of Rho-kinase inhibition to the multiple biological activities of adlay seeds and provide a rationale for their folkloric medicines. Hence, we evaluated Rho-kinase I and II inhibitory activity of the ethanol extract and 28 compounds derived from the seeds. A molecular docking assay was designed to estimate the binding affinity of the tested compounds with the target enzymes. The results of our study suggest a possible involvement of Rho-kinase inhibition to the multiple biological activities of the seeds. Furthermore, the results obtained with the tested compounds revealed some interesting skeletons as a scaffold for design and development of natural Rho-kinase inhibitors.

元の言語英語
ページ(範囲)1955-1959
ページ数5
ジャーナルNatural Product Research
32
発行部数16
DOI
出版物ステータス出版済み - 8 18 2018

Fingerprint

Coix lacryma-jobi
rho-Associated Kinases
Seed
Seeds
phosphotransferases (kinases)
seeds
Bioactivity
bioactive properties
Enzymes
enzymes
glaucoma
Skeleton
Scaffolds
Glaucoma
hypertension
Medicine
skeleton
Assays
medicine
Ethanol

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Biochemistry
  • Plant Science
  • Organic Chemistry

これを引用

Amen, Y., Zhu, Q., Tran, H. B., Afifi, M. S., Halim, A. F., Ashour, A., ... Shimizu, K. (2018). Rho-kinase inhibitors from adlay seeds. Natural Product Research, 32(16), 1955-1959. https://doi.org/10.1080/14786419.2017.1354183

Rho-kinase inhibitors from adlay seeds. / Amen, Yhiya; Zhu, Qinchang; Tran, Hai Bang; Afifi, Mohamed S.; Halim, Ahmed F.; Ashour, Ahmed; Fujimoto, Ryoji; Goto, Takahiro; Shimizu, Kuniyoshi.

:: Natural Product Research, 巻 32, 番号 16, 18.08.2018, p. 1955-1959.

研究成果: ジャーナルへの寄稿記事

Amen, Y, Zhu, Q, Tran, HB, Afifi, MS, Halim, AF, Ashour, A, Fujimoto, R, Goto, T & Shimizu, K 2018, 'Rho-kinase inhibitors from adlay seeds', Natural Product Research, 巻. 32, 番号 16, pp. 1955-1959. https://doi.org/10.1080/14786419.2017.1354183
Amen Y, Zhu Q, Tran HB, Afifi MS, Halim AF, Ashour A その他. Rho-kinase inhibitors from adlay seeds. Natural Product Research. 2018 8 18;32(16):1955-1959. https://doi.org/10.1080/14786419.2017.1354183
Amen, Yhiya ; Zhu, Qinchang ; Tran, Hai Bang ; Afifi, Mohamed S. ; Halim, Ahmed F. ; Ashour, Ahmed ; Fujimoto, Ryoji ; Goto, Takahiro ; Shimizu, Kuniyoshi. / Rho-kinase inhibitors from adlay seeds. :: Natural Product Research. 2018 ; 巻 32, 番号 16. pp. 1955-1959.
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