Ribosome induces transdifferentiation of A549 and H-111-TC cancer cell lines

Mohammad Badrul Anam, Arif Istiaq, Ryusho Kariya, Mikiko Kudo, Shah Adil Ishtiyaq Ahmad, Naofumi Ito, Seiji Okada, Kunimasa Ohta

研究成果: Contribution to journalArticle査読

抄録

Previously we reported that, lactic acid bacteria (LAB) can induce human dermal fibroblast (HDF) cells to form multipotent cell clusters which are able to transdifferentiate into three germ layer derived cell lineages. Later on, we confirmed that ribosome is responsible for the LAB-induced transdifferentiation and ribosomes from diverse organisms can mimic the LAB effect on HDF cells. In our present study we have shown that, upon incorporation of ribosomes, non-small cell lung cancer cell line A549 and gastric tubular adenocarcinoma cell line H-111-TC are transformed into spheroid like morphology those can be transdifferentiated into adipocytes and osteoblast. Our qPCR analysis has revealed that, during the formation of ribosome induced cancer cell spheroids, the expression of the cancer cell associated markers and cell cycle/proliferation markers were altered at different time point. Through our investigation, here we report a novel and a non-invasive approach for cancer cell reprogramming by incorporating ribosomes.

本文言語英語
論文番号100946
ジャーナルBiochemistry and Biophysics Reports
26
DOI
出版ステータス出版済み - 7 2021

All Science Journal Classification (ASJC) codes

  • 生物理学
  • 生化学

フィンガープリント

「Ribosome induces transdifferentiation of A549 and H-111-TC cancer cell lines」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル