RIP kinase-mediated necrosis as an alternative mechanism of photoreceptor death

Yusuke Murakami, Joan W. Miller, Demetrios G. Vavvas

研究成果: Contribution to journalArticle査読

35 被引用数 (Scopus)

抄録

Photoreceptor cell death is the terminal event in a variety of retinal disorders including age-related macular degeneration, retinitis pigmentosa, and retinal detachment. Apoptosis has been thought to be the major form of cell death in these diseases, however accumulating evidence suggests that another pathway, programmed necrosis is also important. Recent studies have shown that, when caspase pathways are blocked, receptor interacting protein (RIP) kinases promote necrosis and overcome apoptosis inhibition. Therefore, targeting of both caspase and RIP kinase pathways are required for effective photoreceptor protection. Here, we summarize the current knowledge of RIP kinase-mediated necrotic signaling and its contribution to photoreceptor death.

本文言語英語
ページ(範囲)497-509
ページ数13
ジャーナルOncotarget
2
6
DOI
出版ステータス出版済み - 6 2011
外部発表はい

All Science Journal Classification (ASJC) codes

  • 腫瘍学

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