RIP Kinase-mediated programmed necrosis

Yusuke Murakami, Maki Kayama, Joan W. Miller, Demetrios Vavvas

研究成果: Chapter in Book/Report/Conference proceedingChapter


Retinal ganglion cell (RGC) death is the ultimate cause of vision loss in glaucoma. Apoptosis has been thought to be a major form of cell death in various diseases including glaucoma; however, attempts to develop neuroprotective agents that target apoptosis have largely failed. Recent accumulating evidence has shown that non-apoptotic forms of cell death such as necrosis are also regulated by specific molecular machinery, such as those mediated by receptor-interacting protein (RIP) kinases. In this review, we summarize recent advances in our understanding of RIP kinase signaling and its roles in RGC loss. These data suggest that not only apoptosis but also necrosis is involved in RGC death and that combined targeting of these pathways may be an effective strategy for glaucoma.

ホスト出版物のタイトルNeuroprotection and Neuroregeneration for Retinal Diseases
出版社Springer Japan
ISBN(印刷版)4431549641, 9784431549642
出版ステータス出版済み - 5 1 2014

All Science Journal Classification (ASJC) codes

  • Medicine(all)

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