Risk Factors and Prediction of Long-term Outcome in Primary Biliary Cirrhosis

Hiromi Ishibashi, Atsumasa Komori, Shinji Shimoda, Yoko M. Ambrosini, M. Eric Gershwin, Minoru Nakamura

研究成果: Contribution to journalReview article査読

28 被引用数 (Scopus)

抄録

The natural history of the disease varies greatly among individual patients with primary biliary cirrhosis (PBC). Some patients live long without any symptoms while other patients present jaundice and develop hepatic failure in early phases of the disease. Previous studies showed that the natural course of PBC is altered by the use of ursodeoxy cholic acid (UDCA). In this review we discuss variation in the natural course of the disease and it's alteration by UDCA, and risk factors that predict disease progression. Based on clinical observations, there are three types of clinical evolution in PBC: 1) minimal to slow progression over several years; 2) rapid progression to jaundice and hepatic failure, and 3) progression to portal hypertension without developing deep jaundice. Notably, based on our analyses accelerated progression to jaundice and liver failure are reflected by a sustained serologic presence of anti-gp210 antibodies whereas patients with portal hypertension in the absence of jaundice have anti-centromere autoantibodies. These observations highlight the clinical importance of antinuclear antibody analysis in patients with PBC.

本文言語英語
ページ(範囲)1-10
ページ数10
ジャーナルInternal Medicine
50
1
DOI
出版ステータス出版済み - 2011
外部発表はい

All Science Journal Classification (ASJC) codes

  • Internal Medicine

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