Risk factors for early recurrence after curative hepatectomy for colorectal liver metastases

Yo Ichi Yamashita, Eisuke Adachi, Yasushi Toh, Kippei Ohgaki, Osamu Ikeda, Eiji Oki, Kazuhito Minami, Yoshihisa Sakaguchi, Eiji Tsujita, Takeshi Okamura

研究成果: ジャーナルへの寄稿記事

17 引用 (Scopus)

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Purpose. With the broadening indications for hepatectomy to treat colorectal liver metastases (CRLM), early recurrence is a major problem. The aim of this study is to identify risk factors of early recurrence, defi ned as recurrence within 1 year after surgery. Methods. A retrospective analysis was performed on 121 consecutive patients who underwent hepatectomy for CRLM. Results. Among 121 patients, 52 (43.0%) developed early recurrence. The independent risk factor for early recurrence was "number of liver metastases ≥3" (odds ratio 2.65). There were signifi cantly more patients with liver recurrence (51.9%) and recurrence beyond curative surgical resection (63.5%) in those with early recurrence. In addition, patients with three or more liver metastases had signifi cantly more liver recurrence (66.7%; P = 0.02) and recurrence beyond curative surgical resection (70.8%; P = 0.04). The overall survival rates of both patients with early recurrence (5-year survival rate 20%) and those with three or more liver metastases (5-year survival rate 24%) were signifi cantly worse. Conclusions. The independent risk factor for early recurrence is the "number of liver metastases ≥3." Patients with three or more liver metastases have a signifi cantly higher risk of liver recurrence and a higher rate of recurrence beyond curative surgical resection, and these are correlated with a poor prognosis.

元の言語英語
ページ(範囲)526-532
ページ数7
ジャーナルSurgery today
41
発行部数4
DOI
出版物ステータス出版済み - 4 1 2011

    フィンガープリント

All Science Journal Classification (ASJC) codes

  • Surgery

これを引用

Yamashita, Y. I., Adachi, E., Toh, Y., Ohgaki, K., Ikeda, O., Oki, E., ... Okamura, T. (2011). Risk factors for early recurrence after curative hepatectomy for colorectal liver metastases. Surgery today, 41(4), 526-532. https://doi.org/10.1007/s00595-010-4471-1