Risk factors for gastric-tube dependence following tongue reconstruction

Shimpei Miyamoto, Minoru Sakuraba, Shogo Nagamatsu, Shuji Kayano, Kenichi Kamizono, Ryuichi Hayashi

研究成果: ジャーナルへの寄稿評論記事

14 引用 (Scopus)

抄録

Background. Postoperative dysphagia is not uncommon following significant glossectomy with laryngeal preservation. To develop effective treatments for this patient population, risk factors for postoperative dysphagia must be accurately identified. The objective of this retrospective study was to identify independent risk factors for dysphagia following microvascular tongue reconstruction. Methods. We performed a retrospective chart review of 222 patients who had undergone microvascular tongue reconstruction after significant glossectomy with laryngeal preservation. The variables examined were age, sex, preoperative body mass index (BMI), history of radiotherapy (RT) to the neck, smoking, alcohol drinking, clinical tumor stage, extent of the defect (tongue, mandible, soft palate, and neck dissection), and postoperative RT. Postoperative dysphagia was defined as gastric-tube dependence for nutrition at the time of evaluation. Possible risk factors for gastric-tube dependence were subjected to univariate analysis and multivariate logistic regression. Results. A total of 33 patients (14.9%) had dysphagia at the time of evaluation. Multivariate logistic regression analysis identified age ≥ 70 years, BMI <18.5 kg/m 2, and, most significantly, postoperative RT as significant risk factors for gastric-tube dependence after tongue reconstruction. Clinical tumor stage (stage IV/recurrence), subtotal or total glossectomy and full-thickness resection of the soft palate were identified as significant factors on univariate analysis but not on multivariate analysis. Conclusions. The present study has identified age ≥ 70 years, BMI <18.5 kg/m 2, and, especially, postoperative RT as significant risk factors for gastric-tube dependence after tongue reconstruction. These factors should be considered when selecting treatments for patients with advanced oral and oropharyngeal cancers.

元の言語英語
ページ(範囲)2320-2326
ページ数7
ジャーナルAnnals of Surgical Oncology
19
発行部数7
DOI
出版物ステータス出版済み - 7 1 2012

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Deglutition Disorders
Tongue
Glossectomy
Stomach
Radiotherapy
Soft Palate
Body Mass Index
Multivariate Analysis
Logistic Models
Oropharyngeal Neoplasms
Neck Dissection
Mouth Neoplasms
Mandible
Alcohol Drinking
Neoplasms
Neck
Retrospective Studies
Smoking
Regression Analysis
Recurrence

All Science Journal Classification (ASJC) codes

  • Surgery
  • Oncology

これを引用

Miyamoto, S., Sakuraba, M., Nagamatsu, S., Kayano, S., Kamizono, K., & Hayashi, R. (2012). Risk factors for gastric-tube dependence following tongue reconstruction. Annals of Surgical Oncology, 19(7), 2320-2326. https://doi.org/10.1245/s10434-012-2298-2

Risk factors for gastric-tube dependence following tongue reconstruction. / Miyamoto, Shimpei; Sakuraba, Minoru; Nagamatsu, Shogo; Kayano, Shuji; Kamizono, Kenichi; Hayashi, Ryuichi.

:: Annals of Surgical Oncology, 巻 19, 番号 7, 01.07.2012, p. 2320-2326.

研究成果: ジャーナルへの寄稿評論記事

Miyamoto, S, Sakuraba, M, Nagamatsu, S, Kayano, S, Kamizono, K & Hayashi, R 2012, 'Risk factors for gastric-tube dependence following tongue reconstruction', Annals of Surgical Oncology, 巻. 19, 番号 7, pp. 2320-2326. https://doi.org/10.1245/s10434-012-2298-2
Miyamoto S, Sakuraba M, Nagamatsu S, Kayano S, Kamizono K, Hayashi R. Risk factors for gastric-tube dependence following tongue reconstruction. Annals of Surgical Oncology. 2012 7 1;19(7):2320-2326. https://doi.org/10.1245/s10434-012-2298-2
Miyamoto, Shimpei ; Sakuraba, Minoru ; Nagamatsu, Shogo ; Kayano, Shuji ; Kamizono, Kenichi ; Hayashi, Ryuichi. / Risk factors for gastric-tube dependence following tongue reconstruction. :: Annals of Surgical Oncology. 2012 ; 巻 19, 番号 7. pp. 2320-2326.
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abstract = "Background. Postoperative dysphagia is not uncommon following significant glossectomy with laryngeal preservation. To develop effective treatments for this patient population, risk factors for postoperative dysphagia must be accurately identified. The objective of this retrospective study was to identify independent risk factors for dysphagia following microvascular tongue reconstruction. Methods. We performed a retrospective chart review of 222 patients who had undergone microvascular tongue reconstruction after significant glossectomy with laryngeal preservation. The variables examined were age, sex, preoperative body mass index (BMI), history of radiotherapy (RT) to the neck, smoking, alcohol drinking, clinical tumor stage, extent of the defect (tongue, mandible, soft palate, and neck dissection), and postoperative RT. Postoperative dysphagia was defined as gastric-tube dependence for nutrition at the time of evaluation. Possible risk factors for gastric-tube dependence were subjected to univariate analysis and multivariate logistic regression. Results. A total of 33 patients (14.9{\%}) had dysphagia at the time of evaluation. Multivariate logistic regression analysis identified age ≥ 70 years, BMI <18.5 kg/m 2, and, most significantly, postoperative RT as significant risk factors for gastric-tube dependence after tongue reconstruction. Clinical tumor stage (stage IV/recurrence), subtotal or total glossectomy and full-thickness resection of the soft palate were identified as significant factors on univariate analysis but not on multivariate analysis. Conclusions. The present study has identified age ≥ 70 years, BMI <18.5 kg/m 2, and, especially, postoperative RT as significant risk factors for gastric-tube dependence after tongue reconstruction. These factors should be considered when selecting treatments for patients with advanced oral and oropharyngeal cancers.",
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T1 - Risk factors for gastric-tube dependence following tongue reconstruction

AU - Miyamoto, Shimpei

AU - Sakuraba, Minoru

AU - Nagamatsu, Shogo

AU - Kayano, Shuji

AU - Kamizono, Kenichi

AU - Hayashi, Ryuichi

PY - 2012/7/1

Y1 - 2012/7/1

N2 - Background. Postoperative dysphagia is not uncommon following significant glossectomy with laryngeal preservation. To develop effective treatments for this patient population, risk factors for postoperative dysphagia must be accurately identified. The objective of this retrospective study was to identify independent risk factors for dysphagia following microvascular tongue reconstruction. Methods. We performed a retrospective chart review of 222 patients who had undergone microvascular tongue reconstruction after significant glossectomy with laryngeal preservation. The variables examined were age, sex, preoperative body mass index (BMI), history of radiotherapy (RT) to the neck, smoking, alcohol drinking, clinical tumor stage, extent of the defect (tongue, mandible, soft palate, and neck dissection), and postoperative RT. Postoperative dysphagia was defined as gastric-tube dependence for nutrition at the time of evaluation. Possible risk factors for gastric-tube dependence were subjected to univariate analysis and multivariate logistic regression. Results. A total of 33 patients (14.9%) had dysphagia at the time of evaluation. Multivariate logistic regression analysis identified age ≥ 70 years, BMI <18.5 kg/m 2, and, most significantly, postoperative RT as significant risk factors for gastric-tube dependence after tongue reconstruction. Clinical tumor stage (stage IV/recurrence), subtotal or total glossectomy and full-thickness resection of the soft palate were identified as significant factors on univariate analysis but not on multivariate analysis. Conclusions. The present study has identified age ≥ 70 years, BMI <18.5 kg/m 2, and, especially, postoperative RT as significant risk factors for gastric-tube dependence after tongue reconstruction. These factors should be considered when selecting treatments for patients with advanced oral and oropharyngeal cancers.

AB - Background. Postoperative dysphagia is not uncommon following significant glossectomy with laryngeal preservation. To develop effective treatments for this patient population, risk factors for postoperative dysphagia must be accurately identified. The objective of this retrospective study was to identify independent risk factors for dysphagia following microvascular tongue reconstruction. Methods. We performed a retrospective chart review of 222 patients who had undergone microvascular tongue reconstruction after significant glossectomy with laryngeal preservation. The variables examined were age, sex, preoperative body mass index (BMI), history of radiotherapy (RT) to the neck, smoking, alcohol drinking, clinical tumor stage, extent of the defect (tongue, mandible, soft palate, and neck dissection), and postoperative RT. Postoperative dysphagia was defined as gastric-tube dependence for nutrition at the time of evaluation. Possible risk factors for gastric-tube dependence were subjected to univariate analysis and multivariate logistic regression. Results. A total of 33 patients (14.9%) had dysphagia at the time of evaluation. Multivariate logistic regression analysis identified age ≥ 70 years, BMI <18.5 kg/m 2, and, most significantly, postoperative RT as significant risk factors for gastric-tube dependence after tongue reconstruction. Clinical tumor stage (stage IV/recurrence), subtotal or total glossectomy and full-thickness resection of the soft palate were identified as significant factors on univariate analysis but not on multivariate analysis. Conclusions. The present study has identified age ≥ 70 years, BMI <18.5 kg/m 2, and, especially, postoperative RT as significant risk factors for gastric-tube dependence after tongue reconstruction. These factors should be considered when selecting treatments for patients with advanced oral and oropharyngeal cancers.

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