Risk factors for recurrence of primary sclerosing cholangitis after living donor liver transplantation: A single center experience

Hiroto Egawa, Kaoru Taira, Satoshi Teramukai, Hironori Haga, Yoshihide Ueda, Atsushi Yonezawa, Satohiro Masuda, Hiroaki Tsuji, Eishi Ashihara, Yasutsugu Takada, Shinji Uemoto

研究成果: ジャーナルへの寄稿学術誌査読

42 被引用数 (Scopus)

抄録

We retrospectively reviewed our 10-year experience with living donor liver transplantation (LDLT) in 30 consecutive patients with end-stage primary sclerosing cholangitis (PSC) to determine long-term patient and graft survival and risk factors for recurrence of PSC. For strict diagnosis of recurrence, patients with hepatic artery thrombosis (n = 2), ABO blood type incompatible transplantation (n = 3), and postoperative survival shorter than 1 year (n = 5) were excluded from the study, leaving 20 patients for analysis. Recurrence was diagnosed in 11 patients 26-71 months after transplantation. Multivariate analysis showed that cytomegalovirus diseases within 3 months after transplantation and related donors were independent risk factors for recurrence. When the effects on recurrence were compared among donor-recipient relationships, there were significant differences, especially between nonrelated donors and parents. Multivariate analysis showed that age was an independent risk factor for time to graft loss. Cytomegalovirus prophylaxis and avoidance of related donors are important in reducing PSC recurrence, although this is a preliminary report with limitations due to the small number of patients. LDLT for young patients with PSC using grafts from their parents might have to be avoided where deceased donor liver transplantation is available.

本文言語英語
ページ(範囲)1347-1354
ページ数8
ジャーナルDigestive Diseases and Sciences
54
6
DOI
出版ステータス出版済み - 6月 2009

!!!All Science Journal Classification (ASJC) codes

  • 生理学
  • 消化器病学

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