Risk factors for reflux esophagitis after eradication of Helicobacter pylori

Akira Harada, Koichi Kurahara, Tomohiko Moriyama, Takahide Tanaka, Yutaka Nagata, Keisuke Kawasaki, Hiroki Yaita, Yuji Maehata, Junji Umeno, Yumi Oshiro, Tadahiko Fuchigami, Takanari Kitazono, Motohiro Esaki, Takayuki Matsumoto

研究成果: ジャーナルへの寄稿記事

抄録

Objective: While there is an association between successful eradication of Helicobacter pylori (HP) and reflux esophagitis (RE), risk factors associated with RE remain obscure. The aim of this study is to determine risk factors associated with the development of RE after HP eradication. Materials and methods: Among all patients treated with successful HP eradication from 2008 to 2016, we retrospectively analyzed those who were free from RE at initial esophagogastroduodenoscopy (EGD) and who were followed up with EGD after eradication. Patients were classified according to the presence or absence of RE at the follow-up EGD. RE was defined as mucosal breaks proximal to the squamous-columnar junction. Demographic data, underlying diseases, medications and endoscopic findings at the initial EGD were compared between patients with and without RE. Results: Among 1575 patients, 142 (9.0%) had RE at the follow-up EGD. The time interval from HP eradication until EGD ranged from 4 to 24 months. The endoscopic grade of RE was higher in males than in females. Multivariate analysis revealed that male sex (odds ratio [OR], 1.51; 95% confidence interval [CI], 1.04–2.24), body mass index ≥25 kg/m2 (OR, 2.91; 95% CI, 2.00–4.22), use of calcium channel blockers (OR, 1.70; 95% CI, 1.12–2.55), and hiatal hernia (OR, 3.46; 95% CI, 2.41–5.00) were associated with the development of RE. Conclusions: Calcium channel blocker use was found to be a risk factor for the development of RE after eradication of HP.

元の言語英語
ページ(範囲)1183-1188
ページ数6
ジャーナルScandinavian Journal of Gastroenterology
54
発行部数10
DOI
出版物ステータス出版済み - 10 3 2019

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Peptic Esophagitis
Helicobacter pylori
Digestive System Endoscopy
Odds Ratio
Confidence Intervals
Calcium Channel Blockers
Hiatal Hernia
Sex Ratio
Body Mass Index
Multivariate Analysis
Demography

All Science Journal Classification (ASJC) codes

  • Gastroenterology

これを引用

Risk factors for reflux esophagitis after eradication of Helicobacter pylori. / Harada, Akira; Kurahara, Koichi; Moriyama, Tomohiko; Tanaka, Takahide; Nagata, Yutaka; Kawasaki, Keisuke; Yaita, Hiroki; Maehata, Yuji; Umeno, Junji; Oshiro, Yumi; Fuchigami, Tadahiko; Kitazono, Takanari; Esaki, Motohiro; Matsumoto, Takayuki.

:: Scandinavian Journal of Gastroenterology, 巻 54, 番号 10, 03.10.2019, p. 1183-1188.

研究成果: ジャーナルへの寄稿記事

Harada, A, Kurahara, K, Moriyama, T, Tanaka, T, Nagata, Y, Kawasaki, K, Yaita, H, Maehata, Y, Umeno, J, Oshiro, Y, Fuchigami, T, Kitazono, T, Esaki, M & Matsumoto, T 2019, 'Risk factors for reflux esophagitis after eradication of Helicobacter pylori', Scandinavian Journal of Gastroenterology, 巻. 54, 番号 10, pp. 1183-1188. https://doi.org/10.1080/00365521.2019.1671487
Harada, Akira ; Kurahara, Koichi ; Moriyama, Tomohiko ; Tanaka, Takahide ; Nagata, Yutaka ; Kawasaki, Keisuke ; Yaita, Hiroki ; Maehata, Yuji ; Umeno, Junji ; Oshiro, Yumi ; Fuchigami, Tadahiko ; Kitazono, Takanari ; Esaki, Motohiro ; Matsumoto, Takayuki. / Risk factors for reflux esophagitis after eradication of Helicobacter pylori. :: Scandinavian Journal of Gastroenterology. 2019 ; 巻 54, 番号 10. pp. 1183-1188.
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abstract = "Objective: While there is an association between successful eradication of Helicobacter pylori (HP) and reflux esophagitis (RE), risk factors associated with RE remain obscure. The aim of this study is to determine risk factors associated with the development of RE after HP eradication. Materials and methods: Among all patients treated with successful HP eradication from 2008 to 2016, we retrospectively analyzed those who were free from RE at initial esophagogastroduodenoscopy (EGD) and who were followed up with EGD after eradication. Patients were classified according to the presence or absence of RE at the follow-up EGD. RE was defined as mucosal breaks proximal to the squamous-columnar junction. Demographic data, underlying diseases, medications and endoscopic findings at the initial EGD were compared between patients with and without RE. Results: Among 1575 patients, 142 (9.0{\%}) had RE at the follow-up EGD. The time interval from HP eradication until EGD ranged from 4 to 24 months. The endoscopic grade of RE was higher in males than in females. Multivariate analysis revealed that male sex (odds ratio [OR], 1.51; 95{\%} confidence interval [CI], 1.04–2.24), body mass index ≥25 kg/m2 (OR, 2.91; 95{\%} CI, 2.00–4.22), use of calcium channel blockers (OR, 1.70; 95{\%} CI, 1.12–2.55), and hiatal hernia (OR, 3.46; 95{\%} CI, 2.41–5.00) were associated with the development of RE. Conclusions: Calcium channel blocker use was found to be a risk factor for the development of RE after eradication of HP.",
author = "Akira Harada and Koichi Kurahara and Tomohiko Moriyama and Takahide Tanaka and Yutaka Nagata and Keisuke Kawasaki and Hiroki Yaita and Yuji Maehata and Junji Umeno and Yumi Oshiro and Tadahiko Fuchigami and Takanari Kitazono and Motohiro Esaki and Takayuki Matsumoto",
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T1 - Risk factors for reflux esophagitis after eradication of Helicobacter pylori

AU - Harada, Akira

AU - Kurahara, Koichi

AU - Moriyama, Tomohiko

AU - Tanaka, Takahide

AU - Nagata, Yutaka

AU - Kawasaki, Keisuke

AU - Yaita, Hiroki

AU - Maehata, Yuji

AU - Umeno, Junji

AU - Oshiro, Yumi

AU - Fuchigami, Tadahiko

AU - Kitazono, Takanari

AU - Esaki, Motohiro

AU - Matsumoto, Takayuki

PY - 2019/10/3

Y1 - 2019/10/3

N2 - Objective: While there is an association between successful eradication of Helicobacter pylori (HP) and reflux esophagitis (RE), risk factors associated with RE remain obscure. The aim of this study is to determine risk factors associated with the development of RE after HP eradication. Materials and methods: Among all patients treated with successful HP eradication from 2008 to 2016, we retrospectively analyzed those who were free from RE at initial esophagogastroduodenoscopy (EGD) and who were followed up with EGD after eradication. Patients were classified according to the presence or absence of RE at the follow-up EGD. RE was defined as mucosal breaks proximal to the squamous-columnar junction. Demographic data, underlying diseases, medications and endoscopic findings at the initial EGD were compared between patients with and without RE. Results: Among 1575 patients, 142 (9.0%) had RE at the follow-up EGD. The time interval from HP eradication until EGD ranged from 4 to 24 months. The endoscopic grade of RE was higher in males than in females. Multivariate analysis revealed that male sex (odds ratio [OR], 1.51; 95% confidence interval [CI], 1.04–2.24), body mass index ≥25 kg/m2 (OR, 2.91; 95% CI, 2.00–4.22), use of calcium channel blockers (OR, 1.70; 95% CI, 1.12–2.55), and hiatal hernia (OR, 3.46; 95% CI, 2.41–5.00) were associated with the development of RE. Conclusions: Calcium channel blocker use was found to be a risk factor for the development of RE after eradication of HP.

AB - Objective: While there is an association between successful eradication of Helicobacter pylori (HP) and reflux esophagitis (RE), risk factors associated with RE remain obscure. The aim of this study is to determine risk factors associated with the development of RE after HP eradication. Materials and methods: Among all patients treated with successful HP eradication from 2008 to 2016, we retrospectively analyzed those who were free from RE at initial esophagogastroduodenoscopy (EGD) and who were followed up with EGD after eradication. Patients were classified according to the presence or absence of RE at the follow-up EGD. RE was defined as mucosal breaks proximal to the squamous-columnar junction. Demographic data, underlying diseases, medications and endoscopic findings at the initial EGD were compared between patients with and without RE. Results: Among 1575 patients, 142 (9.0%) had RE at the follow-up EGD. The time interval from HP eradication until EGD ranged from 4 to 24 months. The endoscopic grade of RE was higher in males than in females. Multivariate analysis revealed that male sex (odds ratio [OR], 1.51; 95% confidence interval [CI], 1.04–2.24), body mass index ≥25 kg/m2 (OR, 2.91; 95% CI, 2.00–4.22), use of calcium channel blockers (OR, 1.70; 95% CI, 1.12–2.55), and hiatal hernia (OR, 3.46; 95% CI, 2.41–5.00) were associated with the development of RE. Conclusions: Calcium channel blocker use was found to be a risk factor for the development of RE after eradication of HP.

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