RNA Tectonics (tectoRNA) for RNA nanostructure design and its application in synthetic biology

Junya Ishikawa, Hiroyuki Furuta, Yoshiya Ikawa

    研究成果: ジャーナルへの寄稿総説査読

    35 被引用数 (Scopus)

    抄録

    RNA molecules are versatile biomaterials that act not only as DNA-like genetic materials but also have diverse functions in regulation of cellular biosystems. RNA is capable of regulating gene expression by sequence-specific hybridization. This feature allows the design of RNA-based artificial gene regulators (riboregulators). RNA can also build complex two-dimensional (2D) and 3D nanostructures, which afford protein-like functions and make RNA an attractive material for nanobiotechnology. RNA tectonics is a methodology in RNA nanobiotechnology for the design and construction of RNA nanostructures/nanoobjects through controlled self-assembly of modular RNA units (tectoRNAs). RNA nanostructures designed according to the concept of RNA tectonics are also attractive as tools in synthetic biology, but in vivo RNA tectonics is still in the early stages. This review presents a summary of the achievements of RNA tectonics and its related researches in vitro, and also introduces recent developments that facilitated the use of RNA nanostructures in bacterial cells.

    本文言語英語
    ページ(範囲)651-664
    ページ数14
    ジャーナルWiley Interdisciplinary Reviews: RNA
    4
    6
    DOI
    出版ステータス出版済み - 11月 2013

    All Science Journal Classification (ASJC) codes

    • 生化学
    • 分子生物学

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