Role of 5-hydroxytryptamine 2C receptors in marble-burying behavior in mice

Nobuaki Egashira, Ryoko Okuno, Atsunori Shirakawa, Masaki Nagao, Kenichi Mishima, Katsunori Iwasaki, Ryozo Oishi, Michihiro Fujiwara

研究成果: Contribution to journalArticle査読

11 被引用数 (Scopus)

抄録

We examined the role of 5-hydroxytryptamine 2C (5-HT 2C) receptors in marble-burying behavior in mice. When administered alone, the selective 5-HT 2C agonist WAY161503 (3 mg/kg) inhibited marble-burying behavior. Moreover, the selective 5-HT 2C antagonist SB242084 (3 mg/kg) reversed the inhibition of marble-burying behavior by 2,5-dimethoxy-4-iodoamphetamine (DOI) (1 mg/kg) or WAY161503 (3 mg/kg). Similarly, SB242084 (1 mg/kg) reversed the inhibition of marble-burying behavior by fluvoxamine (30 mg/kg) or paroxetine (3 mg/kg). These results suggest that 5-HT 2C receptors play a role in marble-burying behavior in mice.

本文言語英語
ページ(範囲)376-379
ページ数4
ジャーナルBiological and Pharmaceutical Bulletin
35
3
DOI
出版ステータス出版済み - 3 2012

All Science Journal Classification (ASJC) codes

  • 薬理学
  • 薬科学

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