Role of 5-Hydroxytryptamine2C Receptors in Marble-Burying Behavior in Mice

Nobuaki Egashira; Ryoko Okuno; Atsunori Shirakawa; Masaki Nagao; Kenichi Mishima; Katsunori Iwasaki; Ryozo Oishi; Michihiro Fujiwara

doi:10.1248/bpb.35.376

Role of 5-Hydroxytryptamine2C Receptors in Marble-Burying Behavior in Mice

Nobuaki Egashira, Ryoko Okuno, Atsunori Shirakawa, Masaki Nagao, Kenichi Mishima, Katsunori Iwasaki, Ryozo Oishi, Michihiro Fujiwara

薬剤部

研究成果: Contribution to journal › Article › 査読

抄録

We examined the role of 5-hydroxytryptamine2C (5-HT2C) receptors in marble-burying behavior in mice. When administered alone, the selective 5-HT2C agonist WAY161503 (3 mg/kg) inhibited marble-burying behavior. Moreover, the selective 5-HT2C antagonist SB242084 (3 mg/kg) reversed the inhibition of marble-burying behavior by 2,5-dimethoxy-4-iodoamphetamine (DOI) (1 mg/kg) or WAY161503 (3 mg/kg). Similarly, SB242084 (1 mg/kg) reversed the inhibition of marble-burying behavior by fluvoxamine (30 mg/kg) or paroxetine (3 mg/kg). These results suggest that 5-HT2C receptors play a role in marble-burying behavior in mice.

本文言語	英語
ページ（範囲）	376-379
ページ数	4
ジャーナル	Biological and Pharmaceutical Bulletin
巻	35
号	3
DOI	https://doi.org/10.1248/bpb.35.376
出版ステータス	出版済み - 2012

文献へのアクセス

10.1248/bpb.35.376

フィンガープリント「Role of 5-Hydroxytryptamine2C Receptors in Marble-Burying Behavior in Mice」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル

@article{1ff10f4d4f594c92bb6b9f3a9f2b29c2,

title = "Role of 5-Hydroxytryptamine2C Receptors in Marble-Burying Behavior in Mice",

abstract = "We examined the role of 5-hydroxytryptamine2C (5-HT2C) receptors in marble-burying behavior in mice. When administered alone, the selective 5-HT2C agonist WAY161503 (3 mg/kg) inhibited marble-burying behavior. Moreover, the selective 5-HT2C antagonist SB242084 (3 mg/kg) reversed the inhibition of marble-burying behavior by 2,5-dimethoxy-4-iodoamphetamine (DOI) (1 mg/kg) or WAY161503 (3 mg/kg). Similarly, SB242084 (1 mg/kg) reversed the inhibition of marble-burying behavior by fluvoxamine (30 mg/kg) or paroxetine (3 mg/kg). These results suggest that 5-HT2C receptors play a role in marble-burying behavior in mice.",

author = "Nobuaki Egashira and Ryoko Okuno and Atsunori Shirakawa and Masaki Nagao and Kenichi Mishima and Katsunori Iwasaki and Ryozo Oishi and Michihiro Fujiwara",

year = "2012",

doi = "10.1248/bpb.35.376",

language = "English",

volume = "35",

pages = "376--379",

journal = "Biological and Pharmaceutical Bulletin",

issn = "0918-6158",

publisher = "Pharmaceutical Society of Japan",

number = "3",

}

TY - JOUR

T1 - Role of 5-Hydroxytryptamine2C Receptors in Marble-Burying Behavior in Mice

AU - Egashira, Nobuaki

AU - Okuno, Ryoko

AU - Shirakawa, Atsunori

AU - Nagao, Masaki

AU - Mishima, Kenichi

AU - Iwasaki, Katsunori

AU - Oishi, Ryozo

AU - Fujiwara, Michihiro

PY - 2012

Y1 - 2012

N2 - We examined the role of 5-hydroxytryptamine2C (5-HT2C) receptors in marble-burying behavior in mice. When administered alone, the selective 5-HT2C agonist WAY161503 (3 mg/kg) inhibited marble-burying behavior. Moreover, the selective 5-HT2C antagonist SB242084 (3 mg/kg) reversed the inhibition of marble-burying behavior by 2,5-dimethoxy-4-iodoamphetamine (DOI) (1 mg/kg) or WAY161503 (3 mg/kg). Similarly, SB242084 (1 mg/kg) reversed the inhibition of marble-burying behavior by fluvoxamine (30 mg/kg) or paroxetine (3 mg/kg). These results suggest that 5-HT2C receptors play a role in marble-burying behavior in mice.

AB - We examined the role of 5-hydroxytryptamine2C (5-HT2C) receptors in marble-burying behavior in mice. When administered alone, the selective 5-HT2C agonist WAY161503 (3 mg/kg) inhibited marble-burying behavior. Moreover, the selective 5-HT2C antagonist SB242084 (3 mg/kg) reversed the inhibition of marble-burying behavior by 2,5-dimethoxy-4-iodoamphetamine (DOI) (1 mg/kg) or WAY161503 (3 mg/kg). Similarly, SB242084 (1 mg/kg) reversed the inhibition of marble-burying behavior by fluvoxamine (30 mg/kg) or paroxetine (3 mg/kg). These results suggest that 5-HT2C receptors play a role in marble-burying behavior in mice.

U2 - 10.1248/bpb.35.376

DO - 10.1248/bpb.35.376

M3 - Article

VL - 35

SP - 376

EP - 379

JO - Biological and Pharmaceutical Bulletin

JF - Biological and Pharmaceutical Bulletin

SN - 0918-6158

IS - 3

ER -