Role of AhR/ARNT system in skin homeostasis

Masutaka Furue, Masakazu Takahara, Takeshi Nakahara, Hiroshi Uchi

研究成果: Contribution to journalReview article査読

90 被引用数 (Scopus)

抄録

Aryl hydrocarbon receptor (AhR) is a ligand-dependent transcription factor that binds to structurally diverse synthetic and naturally occurring chemicals including dioxins, flavonoids, tryptophan photoproducts, and Malassezia metabolites. Upon binding to its ligands, cytoplasmic AhR translocates to the nucleus, heterodimerizes with aryl hydrocarbon receptor nuclear translocator (ARNT), and mediates numerous biological and toxicological effects by inducing the transcription of various AhR-responsive genes. AhR ligation controls oxidation/antioxidation, epidermal barrier function, photo-induced response, melanogenesis, and innate immunity. This review summarizes recent advances in the understanding of the regulatory mechanisms of skin homeostasis mediated by the AhR/ARNT system.

本文言語英語
ページ(範囲)769-779
ページ数11
ジャーナルArchives of Dermatological Research
306
9
DOI
出版ステータス出版済み - 11 2014

All Science Journal Classification (ASJC) codes

  • 皮膚病学

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